Computer-aided design/computer-aided manufacturing of hydroxyapatite scaffolds for bone reconstruction in jawbone atrophy: a systematic review and case report

Maxillofacial Plastic and Reconstructive Surgery
Umberto GaragiolaSandro De Nardi

Abstract

We reviewed the biological and mechanical properties of porous hydroxyapatite (HA) compared to other synthetic materials. Computer-aided design/computer-aided manufacturing (CAD/CAM) was also evaluated to estimate its efficacy with clinical and radiological assessments. A systematic search of the electronic literature database of the National Library of Medicine (PubMed-MEDLINE) was performed for articles published in English between January 1985 and September 2013. The inclusion criteria were (1) histological evaluation of the biocompatibility and osteoconductivity of porous HA in vivo and in vitro, (2) evaluation of the mechanical properties of HA in relation to its porosity, (3) comparison of the biological and mechanical properties between several biomaterials, and (4) clinical and radiological evaluation of the precision of CAD/CAM techniques. HA had excellent osteoconductivity and biocompatibility in vitro and in vivo compared to other biomaterials. HA grafts are suitable for milling and finishing, depending on the design. In computed tomography, porous HA is a more resorbable and more osteoconductive material than dense HA; however, its strength decreases exponentially with an increase in porosity. Mechanical tests showe...Continue Reading

References

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Citations

Jun 28, 2016·Materials·Vuk Uskoković, Victoria M Wu
Jun 13, 2017·Maxillofacial Plastic and Reconstructive Surgery·Pietro SalvatoriFrancesco Grecchi
Feb 23, 2018·Tissue Engineering. Part C, Methods·Kang-Gon LeeBu-Kyu Lee
Mar 14, 2019·The Journal of Craniofacial Surgery·Ivan Onone GialainArthur Rodriguez Gonzalez Cortes
Aug 15, 2018·Maxillofacial Plastic and Reconstructive Surgery·Gian Paolo BombeccariFrancesco Spadari
Sep 26, 2020·International Journal of Molecular Sciences·Ho-Kyung LimSoo-Hwan Byun
Jul 14, 2019·The Journal of Craniofacial Surgery·Ivan Onone GialainArthur Rodriguez Gonzalez Cortes
Jul 28, 2020·The Journal of Prosthetic Dentistry·Stefano GranataAdolfo Di Fiore

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Methods Mentioned

BETA
biopsies
light
scanning electron microscopy
fluorescence microscopy

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