Computer-aided detection of interstitial abnormalities in chest radiographs using a reference standard based on computed tomography

Medical Physics
Yulia ArzhaevaB van Ginneken

Abstract

A computer-aided detection (CAD) system is presented for the localization of interstitial lesions in chest radiographs. The system analyzes the complete lung fields using a two-class supervised pattern classification approach to distinguish between normal texture and texture affected by interstitial lung disease. Analysis is done pixel-wise and produces a probability map for an image where each pixel in the lung fields is assigned a probability of being abnormal. Interstitial lesions are often subtle and ill defined on x-rays and hence difficult to detect, even for expert radiologists. Therefore a new, semiautomatic method is proposed for setting a reference standard for training and evaluating the CAD system. The proposed method employs the fact that interstitial lesions are more distinct on a computed tomography (CT) scan than on a radiograph. Lesion outlines, manually drawn on coronal slices of a CT scan of the same patient, are automatically transformed to corresponding outlines on the chest x-ray, using manually indicated correspondences for a small set of anatomical landmarks. For the texture analysis, local structures are described by means of the multiscale Gaussian filter bank. The system performance is evaluated with ...Continue Reading

References

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Citations

Jan 26, 2011·Physics in Medicine and Biology·Sang Cheol ParkBin Zheng
Apr 29, 2015·Computational and Mathematical Methods in Medicine·Omar Mohd RijalAziah Ahmad Mahayiddin
Jul 5, 2013·Medical Physics·Laurens HogewegBram van Ginneken
Aug 24, 2011·Medical Physics·E-Fong KaoGin-Chung Liu
Apr 12, 2014·Computer Methods and Programs in Biomedicine·G GarcíaM De Blas
Jul 5, 2011·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Ulaş BağcıDaniel J Mollura
Jul 17, 2009·European Journal of Radiology·Bram van GinnekenMathias Prokop
Jul 25, 2013·IEEE Transactions on Medical Imaging·Laurens HogewegBram van Ginneken
Jan 1, 2009·IEEE Reviews in Biomedical Engineering·Noah LeeJohn K Gohagan
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zeinab MohammadzadehZahra Azadmanjir

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