Computer-aided diagnosis of breast cancer: artificial neural network approach for optimized merging of mammographic features

Academic Radiology
J Y LoC E Floyd

Abstract

An artificial neural network (ANN) approach was developed for the computer-aided diagnosis of mammography using an optimally minimized number of input features. A backpropagation ANN merged nine input features (age plus eight radiographic findings extracted by radiologists) to predict biopsy outcome as its output. The features were ranked, and more important ones were selected to produce an optimal subset of features. Given all nine features, the ANN performed with a receiver operator characteristic area under the curve (Az) of .95 +/- .01. Given only the four most important features, the ANN performed with an Az of .96 +/- .01. Although not significantly better than the ANN with all nine features, the ANN with the four optimized features was significantly better than expert radiologists' Az of .90 +/- .02 (p = .01). This four-feature ANN had a 95% sensitivity and an 81% specificity. For cases with calcifications, the radiologists' performance dropped to an Az of .85 +/- .04, whereas a specialized three-feature ANN performed significantly better with an Az of .95 +/- .02 (p = .02). Given only four input features, the ANN predicted biopsy outcome significantly better than did expert radiologists, who also had access to other rad...Continue Reading

References

Mar 1, 1992·AJR. American Journal of Roentgenology·D B Kopans
Jun 1, 1992·Computers and Biomedical Research, an International Journal·S L Ng, W F Bischof
Jun 1, 1991·Investigative Radiology·E A PatrickE I Gruenstein
Jan 1, 1991·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·J S DaPonte, P Sherman
May 1, 1989·Clinical Radiology·I M FreundlichN L Sadowsky
Apr 1, 1988·Investigative Radiology·D J GettyJ A Swets
Oct 9, 1986·Nature·S Sutherland
May 11, 1994·JAMA : the Journal of the American Medical Association·A GargB A Huet
Sep 1, 1994·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·W QianM L Silbiger
Feb 1, 1994·Journal of Digital Imaging·B J LucierL P Clarke
Jan 1, 1992·IEEE Transactions on Medical Imaging·S C AmarturY Takefuji

❮ Previous
Next ❯

Citations

Jan 1, 1997·Computers in Biology and Medicine·C E KahnP Haddawy
Jan 30, 2004·Academic Radiology·Estanislao AranaRoberto Paredes
Apr 29, 1999·International Journal of Medical Informatics·X H WangY H Chang
Oct 20, 2005·Journal of Bioscience and Bioengineering·Shuta TomidaHiroyuki Honda
Feb 21, 2003·Annals of the New York Academy of Sciences·Syed HaqueShankar Srinivasan
Oct 24, 2000·AJR. American Journal of Roentgenology·C E FloydG D Tourassi
Jan 24, 2002·AJR. American Journal of Roentgenology·Joseph Y LoCarey E Floyd
Mar 7, 2002·Computers in Biology and Medicine·Mia K MarkeyCarey E Floyd
Apr 17, 2007·Academic Radiology·Wei QianEdward Eikman
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·John KangSushil Beriwal
Jul 8, 1998·Academic Radiology·K S FreedR C Nelson
Mar 17, 1999·Medical Physics·M KallergiJ Gaviria
Feb 22, 2005·Medical Physics·Shiva K DasLawrence B Marks
Sep 24, 1999·Physics in Medicine and Biology·M T MunleyL B Marks

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.