Computer-aided diagnosis with radiogenomics: analysis of the relationship between genotype and morphological changes of the brain magnetic resonance images

Radiological Physics and Technology
Chiharu KaiKunio Doi

Abstract

In the post-genome era, a novel research field, 'radiomics' has been developed to offer a new viewpoint for the use of genotypes in radiology and medicine research which have traditionally focused on the analysis of imaging phenotypes. The present study analyzed brain morphological changes related to the individual's genotype. Our data consisted of magnetic resonance (MR) images of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), as well as their apolipoprotein E (APOE) genotypes. First, statistical parametric mapping (SPM) 12 was used for three-dimensional anatomical standardization of the brain MR images. A total of 30 normal images were used to create a standard normal brain image. Z-score maps were generated to identify the differences between an abnormal image and the standard normal brain. Our experimental results revealed that cerebral atrophies, depending on genotypes, can occur in different locations and that morphological changes may differ between MCI and AD. Using a classifier to characterize cerebral atrophies related to an individual's genotype, we developed a computer-aided diagnosis (CAD) scheme to identify the disease. For the early detection of cerebral diseases, a screening system u...Continue Reading

References

Sep 18, 1993·Lancet·J PoirierS Gauthier
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Sep 21, 2000·Human Brain Mapping·S E JonesI Aharon
Feb 18, 2003·IEEE Transactions on Medical Imaging·Roman GoldenbergMichael Rudzsky
Nov 24, 2004·Seminars in Ultrasound, CT, and MR·Kunio Doi
Nov 24, 2004·Seminars in Ultrasound, CT, and MR·Maryellen L Giger
Jun 1, 2005·Neuroscience Letters·Yoko HirataHirotsugu Samejima
Mar 14, 2007·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Kunio Doi
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Mar 5, 2013·Journal of Alzheimer's Disease : JAD·Miguel Ángel Muñoz-RuizHilkka Soininen
May 21, 2013·Annual Review of Biomedical Engineering·Maryellen L GigerJulia A Schnabel
Mar 22, 2014·Nature·Erika Check Hayden
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Aug 8, 2015·Journal of the American College of Radiology : JACR·Maciej A Mazurowski
Aug 8, 2015·Scientific Reports·Chintan ParmarHugo J W L Aerts
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Feb 3, 2016·Journal of Medical Imaging·Wentian GuoUNKNOWN Tcga Breast Phenotype Research Group
Oct 6, 2016·Dementia and Geriatric Cognitive Disorders Extra·Miguel Ángel Muñoz-RuizPäivi Hartikainen
Jan 4, 2017·Expert Review of Precision Medicine and Drug Development·Vishwa Parekh, Michael A Jacobs

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Citations

Oct 31, 2018·Radiological Physics and Technology·Hidetaka ArimuraMasahiro Yamada
Jun 7, 2019·The Journal of Biological Chemistry·Shibani BhattacharyaZimei Bu
Jan 4, 2020·Radiological Physics and Technology·Hiroshi Fujita
Feb 17, 2021·Nature Biomedical Engineering·Jonathan T C LiuAnant Madabhushi

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