Computer aided-molecular design and synthesis of a high selective molecularly imprinted polymer for solid-phase extraction of furosemide from human plasma

Analytica Chimica Acta
Mohammad Bagher GholivandFarhad Ahmadi

Abstract

Highly selective molecularly imprinted polymers (MIPs) for solid-phase extraction and determination of furosemide in human plasma have been designed and prepared. In order to study the intermolecular interactions in the pre-polymerization mixture and to find a suitable functional monomer in MIP preparation, a computational approach was developed. It was based on the comparison of the binding energy of the complexes between the template and functional monomers. Having confirmed the results of computational method, three MIPs were synthesized with different functional monomers, i.e. acrylamide (AAM), 4-vinylpiridine (4-VP) and acrylonitrile (ACN), and then evaluated using Langmuir-Freundlich (LF) isotherm. Using the MIP prepared by AAM as functional monomer, a molecularly imprinted solid-phase extraction procedure followed by high performance liquid chromatography with ultraviolet detector (MISPE-HPLC-UV) was developed for selective extraction and determination of furosemide in human plasma. For the proposed MISPE-HPLC-UV method, the linearity between responses (peak area) and concentration was found over the range of 75-3500 ng mL(-1) with a linear regression coefficient (R(2)) of 0.997. The limit of detection (LOD) and quantifi...Continue Reading

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Citations

Jul 9, 2013·Journal of Molecular Modeling·Elmer-Rico E Mojica
Dec 11, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shian ZhongYan Wang
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·M TorkashvandF Taherkhani
Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Dorota KlejnDorota Maciejewska
Dec 15, 2010·Biomedical Chromatography : BMC·Prashant Laxman KoleRavi Sheshala
Nov 1, 2011·Journal of Molecular Recognition : JMR·Liora LeviSimcha Srebnik
Apr 5, 2014·Journal of Molecular Recognition : JMR·Michael J WhitcombeIan A Nicholls
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Ekta RoyPrashant K Sharma
May 7, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariusz DanaDorota Maciejewska

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