Computer-assisted cognitive rehabilitation in persons with multiple sclerosis: Results of a multi-site randomized controlled trial with six month follow-up

Disability and Health Journal
Alexa StuifbergenWenhui Zhang

Abstract

The effects of multiple sclerosis (MS) on cognition have gained increasing recognition as one of the major disabling symptoms of the disease. Despite the prevalence of these symptoms and their impact on quality of life, limited attention has been given to strategies that might help manage the cognitive changes commonly experienced by persons with MS. The primary purpose of this study was to determine the effectiveness of a novel computer-assisted cognitive rehabilitation intervention MAPSS-MS (Memory, Attention, Problem Solving Skills in MS) in a multi-site trial with persons with MS. Persons with MS (N = 183) with cognitive concerns were randomly assigned to either the 8-week MAPSS-MS intervention or usual care plus freely available computer games. Participants completed self-report and performance measures of cognitive functioning, compensatory strategies and depression at baseline, immediately after the MAPSS-MS intervention, and three and six months post-intervention. Changes in study outcomes were analyzed using intention to treat methodology, ANOVA with repeated measures, and ANCOVA. Both groups improved significantly on all outcome measures. The intervention group outperformed the comparison group on all measures, and th...Continue Reading

Citations

May 28, 2019·Journal of Telemedicine and Telecare·Sonia Di TellaFrancesca Baglio
Jul 23, 2019·Neurorehabilitation and Neural Repair·Amit LampitNicole T M Hill
Oct 15, 2019·Nursing Research·Heather BeckerAdam C Sales
Aug 31, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Matthew Plow, Marcia Finlayson
Apr 28, 2020·Health Informatics Journal·Claudio Urrea, Daniel Venegas
May 7, 2020·Nature Reviews. Neurology·John DeLucaBrian M Sandroff
Oct 14, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Jessica PoddaGiampaolo Brichetto
Apr 22, 2021·International Journal of MS Care·Alexa StuifbergenFrancisco Perez

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Clinical Trials Mentioned

NCT03200899

Software Mentioned

SPSS
PROMIS
Lumosity
EPT
SAS
MS
MyBrainGames
MyBrain
MAPSS

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