Computer-assisted quantification of occlusion and coil densities on angiographic and histological images of experimental aneurysms

Neurosurgery
C SherifG Bavinzski

Abstract

Occlusion rates (OR) and coil densities were quantified by computer-assisted morphometry on angiograms and histological ground sections of coil-embolized experimental aneurysms. The aims of this study were 1) to develop computer-assisted evaluations of angiographic OR and histometrical OR, 2) to compare these results to subjectively estimated angiographic OR from clinical practice, and 3) to test the correlation between histometrical data of coil density and occlusion. Eight rabbit carotid-bifurcation aneurysms had been followed by digital subtraction angiography (DSA) before and after Guglielmi detachable coil embolization and at sacrifice (1 h to 24 wk postembolization). Angiographic OR was subjectively estimated, then determined by computer-assisted density-gradient distinction on digitized DSAs. Histometrically, maximum length, neck width, total area, recanalized area, and coil-occupied area were measured on digitized and calibrated color micrographs from surface-stained histological ground sections of the aneurysms. Histometrical OR and coil density were calculated as indirect parameters. Subjective versus computer-assisted angiographic OR yielded for one aneurysm, 100% versus 100%, and for three aneurysms less than 90% ve...Continue Reading

References

Nov 5, 1998·Minimally Invasive Neurosurgery : MIN·G BavinzskiB Richling
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·D RoyJ Raymond
Dec 12, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C GrodenH Zeumer
Feb 15, 2002·Neurosurgery·Hans G Böcher-SchwarzAxel Perneczky
Jul 19, 2003·Stroke; a Journal of Cerebral Circulation·Yuichi MurayamaFernando Vinuela

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Citations

May 26, 2011·Journal of Visualized Experiments : JoVE·Camillo SherifSerge Marbacher
Dec 18, 2010·AJNR. American Journal of Neuroradiology·C Sherif, H Plenk
Dec 24, 2011·AJNR. American Journal of Neuroradiology·C SherifL Remonda
Jun 25, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Monika KillerGregory M Cruise
Oct 15, 2011·Microscopy Research and Technique·Sim K SinghraoStjohn Crean
Oct 23, 2010·AJNR. American Journal of Neuroradiology·C SherifJ Fandino
Aug 4, 2018·Biomechanics and Modeling in Mechanobiology·John D HornJason M Ortega
Jan 5, 2018·Journal of Neurointerventional Surgery·Chander SadasivanBarry B Lieber
May 21, 2013·Cardiovascular Engineering and Technology·Chander SadasivanBaruch B Lieber

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