Computer-based evaluation of Alzheimer's disease and mild cognitive impairment patients during a picture description task

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Laura Hernández-DomínguezAndrés Roche-Bergua

Abstract

We present a methodology to automatically evaluate the performance of patients during picture description tasks. Transcriptions and audio recordings of the Cookie Theft picture description task were used. With 25 healthy elderly control (HC) samples and an information coverage measure, we automatically generated a population-specific referent. We then assessed 517 transcriptions (257 Alzheimer's disease [AD], 217 HC, and 43 mild cognitively impaired samples) according to their informativeness and pertinence against this referent. We extracted linguistic and phonetic metrics which previous literature correlated to early-stage AD. We trained two learners to distinguish HCs from cognitively impaired individuals. Our measures significantly (P < .001) correlated with the severity of the cognitive impairment and the Mini-Mental State Examination score. The classification sensitivity was 81% (area under the curve of receiver operating characteristics = 0.79) and 85% (area under the curve of receiver operating characteristics = 0.76) between HCs and AD and between HCs and AD and mild cognitively impaired, respectively. An automated assessment of a picture description task could assist clinicians in the detection of early signs of cogni...Continue Reading

References

May 1, 1985·Brain and Language·D B HierA G Shindler
Sep 1, 1985·Journal of Speech and Hearing Research·M NicholasN Helm-Estabrooks
Feb 1, 1980·The Journal of Speech and Hearing Disorders·K M Yorkston, D R Beukelman
Dec 1, 1962·Brain : a Journal of Neurology·E DE RENZI, L A VIGNOLO
Sep 30, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·K E Forbes-McKay, A Venneri
Sep 11, 2010·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Serguei V S PakhomovDavid S Knopman
Oct 22, 2013·Brain : a Journal of Neurology·Samrah AhmedPeter Garrard
Nov 25, 2014·Methods in Molecular Biology·A Khodabakhsh, C Demiroglu
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Christoph LaskeSid E O'Bryant
Oct 21, 2015·Journal of Alzheimer's Disease : JAD·Kathleen C FraserFrank Rudzicz
Mar 1, 2015·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Alexandra KönigRenaud David
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Meysam AsgariHiroko Dodge

❮ Previous
Next ❯

Citations

Feb 2, 2021·Frontiers in Psychology·R'mani Haulcy, James Glass
Mar 26, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Frédéric Abiven, Sylvie Ratté
Apr 6, 2021·Journal of Alzheimer's Disease : JAD·Juan F Martínez-FlorezJuan F Cardona
Sep 17, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Chorong OhXianhui Wang
Sep 19, 2021·Scientific Reports·Austin Cheng-Yun TsaiYu-Ling Chang

❮ Previous
Next ❯

Software Mentioned

python
speech
FreeLing
_ features

Related Concepts

Related Feeds

Alzheimer's Disease: Transcription

Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.