PMID: 9427899Jan 15, 1998Paper

Computer-controlled minute ventilation in preterm infants undergoing mechanical ventilation

The Journal of Pediatrics
Nelson ClaureE Bancalari

Abstract

Computer-controlled minute ventilation (CCMV) continuously adjusts the ventilator rate to changes in spontaneous respiratory drive and pulmonary mechanics to maintain a preset total minute ventilation. We hypothesized that CCMV would maintain ventilation and oxygenation with fewer mechanical breaths than conventional intermittent mandatory ventilation in very low birth weight infants. Very low birth weight infants in clinically stable condition who were undergoing mechanical ventilation were enrolled. The number of mechanical breaths, total and mechanical expiratory minute ventilation, mean airway pressure, oxygen hemoglobin saturation by pulse oximetry, and transcutaneous partial carbon dioxide and partial oxygen tensions were obtained during intermittent mandatory ventilation and CCMV (45 to 60 minutes) and compared by paired t test. Fifteen infants were studied. Birth weight (median, range) was 700 gm (550 to 1205 gm), gestational age 26 weeks (23 to 34 weeks), age 21 days (3 to 50 days). When switched from intermittent mandatory ventilation to CCMV, the number of mechanical breaths was reduced (15 +/- 2.8 to 8.6 +/- 2.9 breaths per minute, p < 0.001), leading to lower airway pressure (3.97 +/- 1.00 to 3.45 +/- 1.00 cm H2O, ...Continue Reading

References

Jul 1, 1991·Early Human Development·C F Poets, D P Southall
Nov 1, 1986·The Journal of Pediatrics·R J MartinW A Carlo
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
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Nov 1, 1995·The Journal of Pediatrics·J M BolivarE Bancalari

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Citations

Jan 25, 2006·Intensive Care Medicine·Susanne Herber-JonatAndreas Schulze
Feb 28, 2006·Intensive Care Medicine·Helmut D HummlerAxel R Franz
Jun 4, 2008·Intensive Care Medicine·Karen E A BurnsMartin R Lessard
Sep 7, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Nelson Claure, Eduardo Bancalari
Jul 3, 2013·Early Human Development·Nelson Claure, Eduardo Bancalari
Oct 3, 2008·Seminars in Fetal & Neonatal Medicine·Nelson Claure, Eduardo Bancalari
Jan 12, 2001·Seminars in Perinatology·A Schulze
Jan 15, 1998·The Journal of Pediatrics·R H Clark
Aug 5, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Scott O GuthrieWilliam F Walsh
Apr 11, 2008·The Journal of Trauma·Ronald PauldineDavid W Kaczka
Dec 1, 2019·Pediatric Research·Anton H van KaamLuc J I Zimmermann
Jan 1, 2015·Maternal Health, Neonatology and Perinatology·Eduardo Bancalari, Nelson Claure

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