Computer-controlled muscle paralysis with atracurium in the sheep

Anaesthesia and Intensive Care
D G LampardK C Ng

Abstract

Paralysis was maintained in sheep by computer-controlled infusion of atracurium, using the integrated electromyogram as a measure of neuromuscular transmission. A number of experiments were conducted to ascertain the average infusion rate required to achieve a given level of paralysis for one hour. Each experiment yielded a point on a plot of paralysis versus infusion rate. A dose-response curve based upon a simple model of drug receptor interaction at the neuromuscular junction was fitted to the experimental points by least squares and is able to provide a useful explanation of clinically observed behaviour. The recovery time was also measured in each experiment and plotted against both prior level of paralysis and prior average infusion rate.

References

Feb 1, 1983·British Journal of Anaesthesia·E N RobertsonJ F Crul
Jan 1, 1981·British Journal of Anaesthesia·R Hughes, D J Chapple
Jan 1, 1983·British Journal of Anaesthesia·R A MerrettF W Webb
Feb 1, 1980·Anaesthesia and Intensive Care·N CassD G Lampard
Sep 1, 1980·British Journal of Anaesthesia·M I RamzanE J Triggs

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Citations

Oct 26, 2006·Anaesthesia and Intensive Care·N M Cass, T C K Brown

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