Apr 1, 1989

Computer model of cardiac repolarization processes and of the recovery sequence

Computers and Biomedical Research, an International Journal
M Malik, A J Camm

Abstract

A computer model simulating both excitation and recovery processes within a block of heart muscle tissue has been developed and implemented on different IBM PC AT compatible computers. The model incorporates blocks of tissue consisting of several thousand elements and introduces phenomena which are completely or partly omitted in other existing cardiac electrophysiology models. These phenomena include the electric anisotropy of the tissue, different durations of repolarization in different layers of tissue, and the different shapes of action potential which correspond to cells excited when not fully recovered. Implementation of the model on small personal computers requires the use of a special data structure management and an effective algorithmic background. The program of the model is written in PASCAL and uses dynamically allocated data structures and the asynchronous simulation technique of event planing. These techniques are described in detail. The model has been used in various experiments. Results of simulation studies are presented in the form of modeled three-lead electrocardiographic records. The experimental series which are described include basic patterns of regular activation sequences, modeling of premature bea...Continue Reading

  • References27
  • Citations7

Citations

Mentioned in this Paper

Ischemia
In Silico
Ventricular Fibrillation
Personal Computers
Action Potentials
Transcription Initiation
Inclusion Body Myositis (Disorder)
Cardiac Conduction System
Programming Languages
Muscle

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