PMID: 16617293Apr 18, 2006Paper

Computer modeling of secondary fiber development and growth: I. Nonprimate lenses

Molecular Vision
J R KuszakRebecca Zoltoski

Abstract

The purpose of this study was to use qualitative and quantitative structural data from nonprimate lenses with branched (Y and line) sutures to generate computer models (animations) of secondary fiber development and suture formation. A minimum of 12-18 adult lenses/species (mice, cows, frogs, and rabbits) were used in this study. Lenses were analyzed by light (LM), transmission (TEM), and scanning electron microscopy (SEM). Fiber width, thickness, and length were ascertained from micrographs and by using formulations to calculate distances between degrees of latitude and longitude on asymmetrical oblate spheroids. This information was then used to create scale computer assisted drawings (CADs) of fibers at different stages of their development. The CADs were then placed on a timeline and animated to produce dynamic representations of secondary fiber development and growth. Animating secondary fiber development and suture formation with the inclusion of quantifiable differences in fiber dimensions at progressive stages of their differentiation revealed the following: first, there is the presumption that fibers migrate, rotate, and elongate until they reach their sutural destinations is not likely to be correct. When developing f...Continue Reading

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