Computer planning of stereotactic iodine-125 seed brachytherapy for recurrent malignant gliomas

The British Journal of Radiology
S W HughesD G Thomas

Abstract

At St Thomas' Hospital, we have developed a computer program on a Titan graphics supercomputer to plan the stereotactic implantation of iodine-125 seeds for the palliative treatment of recurrent malignant gliomas. Use of the Gill-Thomas-Cosman relocatable frame allows planning and surgery to be carried out at different hospitals on different days. Stereotactic computed tomography (CT) and positron emission tomography (PET) scans are performed and the images transferred to the planning computer. The head, tumour and frame fiducials are outlined on the relevant images, and a three-dimensional model generated. Structures which could interfere with the surgery or radiotherapy, such as major vessels, shunt tubing etc., can also be outlined and included in the display. Catheter target and entry points are set using a three-dimensional cursor controlled by a set of dials attached to the computer. The program calculates and displays the radiation dose distribution within the target volume for various catheter and seed arrangements. The CT co-ordinates of the fiducial rods are used to convert catheter co-ordinates from CT space to frame space and to calculate the catheter insertion angles and depths. The surgically implanted catheters a...Continue Reading

References

Feb 1, 1978·Radiology·V Krishnaswamy
Jan 1, 1992·British Journal of Neurosurgery·A SofatD G Thomas
Nov 1, 1991·The British Journal of Radiology·D L HillP Graves
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S S GillM Brada
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·K WeaverT Phillips
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R K Ten HakenT W Hood
Oct 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·U F RosenowD C Wright
May 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M C SchellK R Working
Nov 1, 1985·International Journal of Radiation Oncology, Biology, Physics·P A FindlayR W Miller
Jan 1, 1993·Journal of Neuro-oncology·N D KitchenD G Thomas

❮ Previous
Next ❯

Citations

Sep 16, 2014·Seminars in Radiation Oncology·John P Kirkpatrick, John H Sampson
Mar 21, 1998·Seminars in Oncology Nursing·R A Strohl
Dec 4, 2009·Journal of Cancer Research and Clinical Oncology·Bo-Lin LiuWei Zhang
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·K HayatT Pigott
Oct 10, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·R J BaleP Lukas
Jun 4, 2005·Journal of Neuro-oncology·Todd W VitazPhilip H Gutin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.