PMID: 1203542Dec 1, 1975Paper

Computer simulation of cell renewal systems

Blut
W Düchting

Abstract

This paper deals with a block diagram which describes the structure of the control of erythropoiesis by negative feedback loops. The model is transformed into an adequate simulation program using a special block-oriented programming language called ASIM (Analoge SIMulation). For both normal and diseased states of the blood forming process the dynamic responses of the erythrocytes and reticulocytes are simulated by a digital computer analysis. The computer simulation includes different forms of anemia caused by parameter variations as well as by structural alterations. Rising oscillations are obtained too in multiloop control systems containing complex paths with minor loops, which for example take into account the erythrocytic chalones. The described model shows that rising oscillations, that are unstable control loops, can be produced by changing the control-loop structure as well as by parameter changes. In case of malignant disorders such failures becoming effective in oscillations are discussed as parts of disturbed homoeostasis. The results of these studies obtained by simulation should especially stimulate scientists working in the fields of biology and medicine to new test series to verify the proposed hypothesis.

References

Feb 1, 1970·Journal of Theoretical Biology·J KirkW M Gray
Jan 1, 1972·The American Journal of Physiology·S J Baum, D E Wyant
Mar 1, 1973·Journal of Theoretical Biology·T E WheldonW M Gray
Jul 1, 1968·British Journal of Haematology·J S OrrJ R Anderson
Feb 1, 1970·Klinische Wochenschrift·I Baciu
Sep 21, 1973·Journal of Theoretical Biology·T E Wheldon, J Kirk
Apr 1, 1974·Journal of Theoretical Biology·J C Barrett
Jul 1, 1970·Experimental Cell Research·I T Boll, G Fuchs
Nov 1, 1971·Journal of Theoretical Biology·K C Mylrea, P H Abbrecht
Feb 1, 1971·Journal of Theoretical Biology·R Tsanev, B Sendov
Mar 1, 1968·Journal of Theoretical Biology·J Kiefer
Jul 1, 1968·British Journal of Haematology·J KirkC S Hope
Nov 1, 1968·Biophysical Journal·B V BronkA Paskin
Sep 1, 1965·The Bulletin of Mathematical Biophysics·E Trucco
Nov 1, 1965·Journal of Theoretical Biology·M YcasA Bensam
Sep 20, 1957·The Journal of General Physiology·P WEISS, J L KAVANAU
Oct 1, 1962·British Journal of Haematology·L G LAJTHAC W GURNEY
Sep 1, 1964·British Journal of Cancer·A K LAIRD

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Citations

Oct 29, 1998·Medizinische Klinik·W Düchting

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