Computer simulation of cerebrovascular circulation: assessment of intracranial hemodynamics during induction of anesthesia

Journal of Clinical Monitoring
A Y BekkerA A Ritter

Abstract

The purpose of this project was to develop a computer model of cerebrovascular hemodynamics interacting with a pharmacokinetic drug model to examine the effects of various stimuli on cerebral blood flow and intracranial pressure during anesthesia. The mathematical model of intracranial hemodynamics is a seven-compartment, constant-volume system. A series of resistance relate blood and cerebrospinal fluid fluxes to pressure gradients between compartments. Arterial, venous, and tissue compliance are also included. Autoregulation is modeled by transmural pressure-dependent, arterial-arteriolar resistance. The effect of a drug (thiopental) on cerebrovascular circulation was simulated by a variable arteriolar-capillary resistance. Thiopental concentration was predicted by a three-compartment, pharmacokinetic model. The effect site compartment was included to account for a disequilibrium between drug plasma and biophase concentrations. The model was validated by comparing simulation results with available experimental observations. The simulation program is written in VisSim dynamic simulation language for an IBM-compatible PC. The model developed was used to calculate the cerebral blood flow and intracranial pressure changes that oc...Continue Reading

References

Sep 1, 1978·Anesthesiology·K E Becker, A S Tonnesen
Dec 1, 1990·Computers and Biomedical Research, an International Journal·M Ursino
Mar 1, 1990·Anesthesiology·C J Hull
Jan 1, 1990·Annals of Biomedical Engineering·O BarneaD Jaron
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·R AaslidH Nornes
Jan 1, 1989·Annals of Biomedical Engineering·R BraakmanN Westerhof
Feb 2, 1989·The American Journal of Cardiology·H Van AkenC Puchstein
Jan 1, 1989·Annals of Biomedical Engineering·S SorekZ Karni
Jan 1, 1989·Annals of Biomedical Engineering·M SharanA S Popel
Jan 1, 1986·International Journal of Clinical Monitoring and Computing·J H Philip
Feb 1, 1987·Computers and Biomedical Research, an International Journal·H A Schwid
Jul 1, 1986·Clinical Pharmacology and Therapeutics·J D UnadkatL B Sheiner
Jan 1, 1986·Journal of Biomechanics·M Zagzoule, J P Marc-Vergnes
May 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·D SenguptaB Jennett
Jun 1, 1972·Computers and Biomedical Research, an International Journal·A ZwartJ E Beneken
Mar 1, 1966·Anesthesiology·L J Saidman, E I Eger
Dec 1, 1980·British Journal of Anaesthesia·C J HullA Sibbald
Sep 1, 1982·Stroke; a Journal of Cerebral Circulation·A G HudetzD D Reneau
Aug 1, 1981·British Journal of Anaesthesia·W J RussellS E Drew
Jul 1, 1992·Journal of Neurosurgical Anesthesiology·A K BaroniaK C Pant

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Citations

Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mette S OlufsenLewis A Lipsitz
Oct 1, 2005·Journal of Mathematical Biology·Andreas JungAlexander Brawanski
Oct 5, 2013·Neurocritical Care·Georgios V VarsosMarek Czosnyka
Apr 2, 2015·PloS One·Simona PanunziAndrea De Gaetano
Sep 8, 2017·Journal of Neuroscience Research·Chiara RobbaMarek Czosnyka

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