Computer simulation of circulation in patient with total cavo-pulmonary connection: inter-relationship of cardiac and vascular pressure, flow, resistance and capacitance

Medical & Biological Engineering & Computing
A RydbergP Krus

Abstract

The aim is to develop a computer model representative of the circulation in a patient with a uni-ventricular heart surgically palliated by a total cavo-pulmonary connection (TCPC). The effects of known hazardous exposures on this type of circulation are investigated. A model of the cardiovascular system is built using standard components such as transmission lines, restrictors and capacitances. The chamber of the heart consists of a volume connected to checkvalves, and an oscillating source flow connected to the volume represents the pumping of the heart. The following are simulated: exposure to cold, heat, high altitude, accelerating forces, blood loss, reduction in ventricular function, atrioventricular-valve regurgitation and treatment with afterload-reducing agents. During simulations, all the parameters can be changed, independently of each other, and the resulting changes in flow, resistance and pressure are recorded. Exposure to cold, reduced ventricular function and atriventricular-valve regurgitation result in a decrease in cardiac output (14, 58 and 45%, respectively). At high altitude, an increase of 18% is noted in the central venous pressure. Afterload-reducing agents increase the cardiac output by 8% and reduce ce...Continue Reading

References

Oct 6, 2007·Pediatric Cardiology·C G DeGroff
Jun 25, 2014·World Journal for Pediatric & Congenital Heart Surgery·Raymond L Watrous, Alvin J Chin
Mar 5, 2008·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Aug 1, 2009·The Indian Journal of Surgery·Anurag SrivastavaJohn Woodcock
Jul 20, 2011·Indian Journal of Nephrology·G MetryN W Levin
Oct 27, 2011·Expert Review of Medical Devices·Maxime CannessonChristoph K Hofer
Mar 10, 2001·Physiological Measurement·Silvio CavalcantiC F Marcelletti
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Elisa MagossoMauro Ursino
Jun 11, 2019·Frontiers in Pediatrics·Antonio F CornoAldo Rona

Citations

May 1, 1971·Thorax·F Fontan, E Baudet
Jan 1, 1980·The American Journal of Cardiology·W I NorwoodS P Sanders
May 1, 1982·The American Journal of Cardiology·S P SandersA R Castaneda
Jan 1, 1994·The Annals of Thoracic Surgery·R W DayE C McGough

Related Concepts

In Silico
Lung
Cardiovascular System
Blood Vessel
Hemi-Fontan Procedure
Postoperative Hemorrhage
Cardiac Catheterization Central Venous Pressure in Centimeters of H20
Congenital Heart Defects
Aorta
Vascular Diseases

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

The Annals of Thoracic Surgery
A R DobellW G Williams
Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
L L MinichR E Shaddy
© 2020 Meta ULC. All rights reserved