Computer simulation of nerve growth cone filopodial dynamics for visualization and analysis

Cell Motility and the Cytoskeleton
Helen M Buettner

Abstract

The neuronal growth cone plays a fundamental role in nerve development and regeneration. A sensory-motile structure, it determines the path of axonal extension through its interactions with the extracellular environment, ultimately directing the formation of functional connections in the nervous system. Though several mechanisms of interaction have been proposed, these have been difficult to describe quantitatively due to the complexity of growth cone behavior, as manifested in the randomly and rapidly changing shape of the growth cone. The application of mathematical techniques to model growth cone shape and motility in terms of underlying processes represents a promising approach with untapped potential for helping to unravel this complexity while revealing new insights into axonal pathfinding events. This paper presents a simulation model for filopodial dynamics, a primary feature of the motile growth cone. The model produces realizations of dynamic filopodial structure on representative growth cones for a given set of model parameters, which include the rates of filopodial initiation, extension, and retraction, filopodial length at maximum extension, and angular orientation. These parameters are based on recent experimental...Continue Reading

References

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Citations

Sep 1, 2005·Journal of Computational Neuroscience·Duncan E Donohue, Giorgio A Ascoli
Oct 13, 2004·Neural Computation·Geoffrey J GoodhillJeffrey S Urbach
May 17, 2008·PLoS Computational Biology·Duncan E Donohue, Giorgio A Ascoli
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Nov 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Daniel J RizzoCristian Staii

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