Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology study.

Schizophrenia Research
N V MurthyR Alexander

Abstract

A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed ≥ 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState® schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState® assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effect...Continue Reading

References

Jul 1, 1990·Schizophrenia Research·D AddingtonB Schissel
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Jul 23, 1998·Neuropsychology·R W Heinrichs, K K Zakzanis
Dec 7, 2007·The American Journal of Psychiatry·Susan R McGurkKim T Mueser
May 19, 2009·The American Journal of Psychiatry·Melissa FisherSophia Vinogradov
Sep 12, 2009·Schizophrenia Bulletin·R Alison AdcockSophia Vinogradov
Dec 17, 2009·The American Journal of Psychiatry·Dwight DickinsonAlan S Bellack

❮ Previous
Next ❯

Citations

May 27, 2014·Archives of Psychiatric Nursing·Jin DangChen Zhang
Feb 4, 2014·Schizophrenia Research·Christopher K CainDonald C Goff
Nov 16, 2013·Psychiatry Journal·Martina HubacherIris-Katharina Penner
Apr 29, 2015·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Akihiro ShiinaKenji Hashimoto
Sep 10, 2013·Biological Psychiatry·Tristram A LettZafiris J Daskalakis
Feb 15, 2015·Pharmacology, Biochemistry, and Behavior·Verner KnottAlain Labelle
Apr 26, 2016·Annals of the New York Academy of Sciences·Melissa FisherSophia Vinogradov
May 25, 2016·Neuropsychological Rehabilitation·Alice MedaliaSeonjoo Lee
Nov 1, 2016·Schizophrenia Bulletin·Neal R SwerdlowGregory A Light
Feb 1, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Veronica B PerezGregory A Light
Jan 22, 2018·Journal of the International Neuropsychological Society : JINS·Shayden D BryceJennie L Ponsford
Nov 1, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William C HochbergerGregory A Light
Feb 12, 2019·Expert Review of Neurotherapeutics·Clément DondéFrédéric Haesebaert
Jan 28, 2020·Journal of the International Neuropsychological Society : JINS·B C CastelluccioJ K Johannesen
Aug 14, 2020·Journal of Psychiatry and Brain Science·Steven M SilversteinPamela D Butler
Jan 16, 2013·Current Opinion in Psychiatry·Alice Medalia, Alice M Saperstein
Jun 19, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Alice M Saperstein, Matthew M Kurtz
Jun 19, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Alice Medalia
Apr 17, 2018·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Joshua T KantrowitzSophia Vinogradov
Dec 13, 2019·Schizophrenia Research. Cognition·Benedetta SeccomandiMatteo Cella

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here