PMID: 16526587Mar 11, 2006Paper

Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptoms

American Journal of Alzheimer's Disease and Other Dementias
Glen M DonigerEly S Simon

Abstract

Cognitive and depressive symptoms co-occur, complicating detection of mild cognitive impairment (MCI) and early dementia. In this study, discriminant validity of a novel computerized cognitive battery for MCI detection was evaluated after covariation for depressive symptom severity. In addition to the computerized battery, participants at two sites received the 30-item self-administered Geriatric Depression Scale (GDS; n=72); those at two other centers received the observer-administered Cornell Scale for Depression in Dementia (CSDD; n=88). In both cohorts, a Global Cognitive Score and memory, executive function, visual spatial, and verbal index scores discriminated among cognitively healthy, MCI, and mild dementia groups after covariation for GDS or CSDD, respectively (p < 0.05). Thus, the computerized battery for detection of mild impairment is robust to comorbid depressive symptoms, supporting its clinical utility in identifying neurodegenerative disease even in elderly with depression.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1991·Psychological Bulletin·C M MacLeod
Dec 1, 1990·Research Quarterly for Exercise and Sport·J H Cauraugh
Feb 1, 1988·Biological Psychiatry·G S AlexopoulosC A Shamoian
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Sep 1, 1995·Journal of the American Geriatrics Society·T HänninenP J Riekkinen
May 1, 1994·Journal of the American Geriatrics Society·S A McGivneyB Taylor
Jan 1, 1997·The American Journal of Psychiatry·C Sobin, H A Sackeim
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Jul 19, 2001·Journal of the International Neuropsychological Society : JINS·M S AlbertK Jones
Apr 2, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jason T OlinBarry D Lebowitz
Apr 2, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jason T OlinBarry D Lebowitz
Aug 2, 2002·Current Opinion in Neurology·Frédéric Assal, Jeffrey L Cummings
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Constantine G LyketsosSteven DeKosky
Feb 1, 2003·Neuropsychologia·Stefan R SchweinbergerBettina Mohr
Feb 5, 2003·Dementia and Geriatric Cognitive Disorders·Philippe H RobertUNKNOWN Investigators' Group
Aug 2, 2003·Biological Psychiatry·Hochang B Lee, Constantine G Lyketsos
Nov 5, 2003·BMC Geriatrics·Tzvi DwolatzkyHoward Chertkow
Feb 17, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Deborah ElsteinAri Zimran
May 3, 2005·Experimental Brain Research·Jeffrey M HausdorffNir Giladi

❮ Previous
Next ❯

Citations

Jun 4, 2010·International Psychogeriatrics·Tzvi DwolatzkyGlen M Doniger
Oct 31, 2008·Journal of Clinical and Experimental Neuropsychology·Grant L IversonC Thomas Gualtieri
Apr 19, 2011·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Amitai AbramovitchHaggai Hermesh
Mar 3, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Russell M BauerRichard I Naugle
Sep 18, 2013·The Clinical Neuropsychologist·Carolyn M Parsey, Maureen Schmitter-Edgecombe
Oct 18, 2008·International Review of Psychiatry·Jeffrey L Cummings
Feb 11, 2016·Parkinsonism & Related Disorders·I MaidanA Mirelman
Dec 8, 2014·Computer Methods and Programs in Biomedicine·Gokhan ZorluogluPinar O Ozanar
Sep 16, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Glen M Doniger, Ely S Simon
Nov 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Katherine WildJeffrey Kaye
Nov 3, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Einor Ben AssayagNatan M Bornstein
Dec 12, 2012·Acta Neurologica Scandinavica·Y BalashA D Korczyn
Apr 17, 2013·International Journal of Geriatric Psychiatry·Mark A EspelandUNKNOWN LIFE Study Group
Dec 11, 2014·Journal of Neural Transmission·Talia HermanJeffrey M Hausdorff
Nov 11, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Dinah ZurAnat Kesler
Aug 25, 2009·American Journal of Alzheimer's Disease and Other Dementias·Glen M DonigerHoward A Crystal
Dec 29, 2013·American Journal of Alzheimer's Disease and Other Dementias·Sayantani GhoshCarol Lippa
Feb 15, 2014·American Journal of Alzheimer's Disease and Other Dementias·Stelios Zygouris, Magda Tsolaki
Jul 21, 2012·American Journal of Alzheimer's Disease and Other Dementias·Alessandro O CaffòAndrea Bosco
Aug 13, 2017·Stroke; a Journal of Cerebral Circulation·Einor Ben AssayagEitan Auriel
Feb 28, 2013·Stroke; a Journal of Cerebral Circulation·Efrat KliperEinor Ben Assayag
Dec 17, 2015·The Journal of ECT·Keren AvirameDoron Todder
Jul 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Howard M FillitJeffrey L Cummings
Sep 29, 2017·Neurology·Inbal MaidanAnat Mirelman
Mar 10, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Daniel GolanMark Gudesblatt
Nov 5, 2008·CNS Spectrums·Ellen Woo
Apr 1, 2014·Dementia & Neuropsychologia·Maira Okada de Oliveira, Sonia Maria Dozzi Brucki
May 11, 2021·Journal of Alzheimer's Disease : JAD·Jeremy MoladEinor Ben Assayag

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.