Computerized digital imaging techniques provided by digital X-ray radiogrammetry as new diagnostic tool in rheumatoid arthritis.

Journal of Digital Imaging
Joachim BöttcherWerner A Kaiser

Abstract

Our study evaluates digital x-ray radiogrammetry (DXR) and Radiogrammetry Kit (RK) as a new diagnostic method for the measurement of disease-related osteoporosis including quantification of joint space narrowing dependent on the severity of rheumatoid arthritis (RA). A total of 172 unselected patients with RA underwent computerized measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as a semiautomated measurement of joint space distances at the metacarpal-phalangeal articulation (JSD-MCP 2-5), both were analyzed from plain radiographs of the nondominant hand. Correlations between DXR-BMD and DXR-MCI vs. parameters of RK were all significant (0.34 < R < 0.61; p < 0.01). An expected negative association was observed between RK parameters and the different scoring methods (-0.27 < R < -0.59). The maximum relative decrease in BMD vs. MCI as measured by DXR between the highest and lowest RA severity group was -27.7% vs. -27.5% (p < 0.01) for the modified Larsen Score, whereas the minimal value of relative DXR-BMD and DXR-MCI reduction could be documented for the Sharp Erosion Score (-20.8% vs. -26.8%; p < 0.01). The relative reduction of mean JSD-MCP using RK significantly varied from -25.0% (Sharp ...Continue Reading

References

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Citations

Feb 22, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L NaumannF Buttgereit
Apr 20, 2010·Rheumatology International·Alexander PfeilJoachim Böttcher
Apr 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Mari Hoff, Glenn Haugeberg
Jan 21, 2009·The British Journal of Radiology·L PearmanP C Brennan
Dec 19, 2012·Joint, Bone, Spine : Revue Du Rhumatisme·Alexander PfeilJoachim Böttcher
May 9, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Max-Ludwig SchäferDiane M Renz
Oct 4, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Alexander PfeilJoachim Böttcher
Aug 26, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Joachim BöttcherWerner A Kaiser
Jul 6, 2014·International Journal of Computer Assisted Radiology and Surgery·Alexander PfeilJoachim Böttcher
Apr 15, 2010·Arthritis Care & Research·John T SharpRichard Newmark
May 11, 2011·Arthritis Care & Research·Alexander PfeilJoachim Böttcher

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