PMID: 10965408Aug 31, 2000Paper

Computerized morphometric study on fine needle aspirates of cellular follicular lesions of the thyroid

Analytical and Quantitative Cytology and Histology
S Tseleni-BalafoutaP Davaris


To investigate the value of computerized nuclear morphometry in the differential diagnosis of cellular follicular lesions of the thyroid cytologically diagnosed on fine needle aspiration (FNA) smears. Sixty cases of FNA thyroid smears were cytologically diagnosed and classified as follows: 30 cases of follicular carcinoma, 20 cases of cellular hyperplastic nodules and 10 cases of follicular adenoma. Using an image analysis system, two morphometric variables, nuclear area and major axis length of the nucleus, were measured for each case. For both nuclear morphometric variables, statistical differences were found between carcinomas and hyperplastic nodules as well as between carcinomas and adenomas. No statistical differences were found between the nuclear variables in either hyperplastic nodules or adenomas. The results confirm the aim of our study, to establish nuclear morphometry by computerized image analysis as an additional tool in the differential diagnosis of thyroid follicular lesions cytologically diagnosed on FNA smears.

Related Concepts

Adenoma, Trabecular
Needle Biopsy Procedure
Cell Nucleus
Differential Diagnosis
Optical Image Reconstruction
Thyroid Gland
Thyroid Gland Follicular Adenoma
Thyroid Nodule
Follicular Thyroid Carcinoma
Cell Volume

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