PMID: 16511796Mar 3, 2006Paper

Computerized morphometry of mean nuclear diameter and nuclear roundness in canine mammary gland tumors on cytologic smears

Veterinary Clinical Pathology
Radostin Simeonov, Galina Simeonova

Abstract

The use of computer-based image analysis systems in veterinary oncology has increased. Computerized morphometry is a part of image analysis that describes geometric figures of cellular structures in any dimension. Most investigators have performed morphometric analysis on histologic specimens. Computer-assisted nuclear cytomorphometry can provide important preoperative information on neoplastic lesions in animals. The aim of this study was to define whether the morphometric parameters of mean nuclear diameter and nuclear roundness could be used to differentiate benign from malignant canine mammary gland tumors on cytologic specimens. Mean nuclear diameter and nuclear roundness were determined by computer-assisted morphometry of epithelial cells in Hemacolor-stained cytologic smears from normal canine mammary gland (n = 7) and from canine mammary adenomas (n = 8), tubulopapillary carcinomas (n = 9), and solid carcinomas (n = 6). Data were analyzed by the Mann-Whitney U test. Significant differences (P <.001) were found in mean nuclear diameter and nuclear roundness among all tumor types and in comparison with normal canine mammary gland epithelial cells (except for nuclear roundness between tubulopapillary carcinomas and solid c...Continue Reading

Citations

Feb 8, 2011·Clinics in Laboratory Medicine·Leslie C Sharkey, Maxey L Wellman
Oct 26, 2007·The Veterinary Journal·R Simeonov, G Simeonova
Dec 1, 2015·Polish Journal of Veterinary Sciences·R PrzeździeckiR Sapierzyński
Aug 27, 2014·Veterinary Clinical Pathology·Beverly A Kidney, Melissa D Meachem
Apr 25, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Melissa D MeachemBeverly A Kidney
Oct 13, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·R S Simeonov, G P Simeonova
Jun 8, 2011·Reproduction in Domestic Animals = Zuchthygiene·N SleeckxL Van Brantegem
Mar 27, 2021·Veterinary Pathology·Giancarlo AvallonePaola Roccabianca
Nov 13, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ricardo MarcosMarta Santos

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