Computerized ST depression analysis improves prediction of all-cause and cardiovascular mortality: the strong heart study

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
P M OkinB V Howard

Abstract

Nonspecific ST depression assessed by standard visual Minnesota coding (MC) has been demonstrated to predict risk. Although computer analysis has been applied to digital ECGs for MC, the prognostic value of computerized MC and computerized ST depression analyses have not been examined in relation to standard visual MC. The predictive value of nonspecific ST depression as determined by visual and computerized MC codes 4.2 or 4.3 was compared with computer-measured ST depression >or= 50 microV in 2,127 American Indian participants in the first Strong Heart Study examination. Computerized MC and ST depression were determined using separate computerized-ECG analysis programs and visual MC was performed by an experienced ECG core laboratory. The prevalence of MC 4.2 or 4.3 by computer was higher than by visual analysis (6.4 vs 4.4%, P < 0.001). After mean follow-up of 3.7 +/- 0.9 years, there were 73 cardiovascular deaths and 227 deaths from all causes. In univariate Cox analyses, visual MC (relative risk [RR] 4.8, 95% confidence interval [CI] 2.6-9.1), computerized MC (RR 6.0, 95% CI 3.5-10.3), and computer-measured ST depression (RR 7.6, 95% CI 4.5-12.9) were all significant predictors of cardiovascular death. In separate multivar...Continue Reading

References

Dec 19, 1991·The New England Journal of Medicine·J L WillemsG van Herpen
May 14, 1988·British Medical Journal·D Machin, M J Gardner
Dec 1, 1987·Journal of the American College of Cardiology·J L WillemsG Mazzocca
Feb 1, 1987·American Heart Journal·B E KregerW B Kannel
Mar 1, 1982·British Heart Journal·K CullenG N Cumpston
May 1, 1995·Journal of the American College of Cardiology·J M DekkerD Kromhout
Jan 1, 1996·Journal of Electrocardiology·P W Macfarlane, S Latif
Jan 1, 1996·Journal of Electrocardiology·J A KorsJ H van Bemmel
Jul 31, 1998·Journal of Electrocardiology·M C de BruyneJ H van Bemmel
Feb 18, 1999·JAMA : the Journal of the American Medical Association·M L DaviglusJ Stamler
Sep 14, 1999·Journal of the American College of Cardiology·M S LauerE J Topol

❮ Previous
Next ❯

Citations

Feb 23, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Seth R BenderPeter M Okin
Oct 24, 2002·Journal of the American College of Cardiology·Peter M OkinUNKNOWN Strong Heart Study
Aug 30, 2014·Journal of the American College of Cardiology·Peter Godsk JørgensenRasmus Mogelvang
Jul 25, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Daniel J FriedmanPeter M Okin
Jun 7, 2005·Journal of the American College of Cardiology·Peter M OkinRichard B Devereux
May 13, 2014·Journal of the American Heart Association·Peter Vibe RasmussenAnders Gaarsdal Holst
Nov 26, 2010·Circulation·Philip GreenlandUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.