Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R

Computer Methods and Programs in Biomedicine
Emmanuelle CometsFrance Mentré

Abstract

Pharmacokinetic/pharmacodynamic data are often analysed using nonlinear mixed-effect models, and model evaluation should be an important part of the analysis. Recently, normalised prediction distribution errors (npde) have been proposed as a model evaluation tool. In this paper, we describe an add-on package for the open source statistical package R, designed to compute npde. npde take into account the full predictive distribution of each individual observation and handle multiple observations within subjects. Under the null hypothesis that the model under scrutiny describes the validation dataset, npde should follow the standard normal distribution. Simulations need to be performed before hand, using for example the software used for model estimation. We illustrate the use of the package with two simulated datasets, one under the true model and one with different parameter values, to show how npde can be used to evaluate models. Model estimation and data simulation were performed using NONMEM version 5.1.

References

Apr 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·S VozehD R Stanski
Dec 1, 1996·Statistical Methods in Medical Research·A Gelman, D B Rubin
Apr 12, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L AaronsUNKNOWN COST B15 Experts
Nov 15, 2005·Journal of Pharmacokinetics and Pharmacodynamics·France Mentré, Sylvie Escolano
Jul 7, 2007·Pharmaceutical Research·Andrew C HookerMats O Karlsson

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Citations

Sep 1, 2012·European Journal of Clinical Pharmacology·Sihem BenaboudMarie Courbebaisse
Apr 17, 2013·European Journal of Clinical Pharmacology·V Guy-ViterboFlora Tshinanu Musuamba
May 16, 2013·Cancer Chemotherapy and Pharmacology·Hoai-Thu ThaiEmmanuelle Comets
Dec 25, 2009·Journal of Pharmacokinetics and Pharmacodynamics·Karl BrendelFrance Mentré
Dec 15, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Venkata V Pavan Kumar, Stephen B Duffull
Jul 26, 2013·The Journal of Antimicrobial Chemotherapy·Manjunath P Pai
Jul 23, 2009·Critical Care : the Official Journal of the Critical Care Forum·Imad AbboudChristophe Faisy
Feb 9, 2011·The AAPS Journal·Martin BergstrandMats O Karlsson
May 28, 2011·The AAPS Journal·Julie BertrandEmmanuelle Comets
Dec 15, 2010·Pharmaceutical Research·Elke H J KrekelsCatherijne A J Knibbe
Jan 17, 2012·European Journal of Clinical Pharmacology·Arantxazu IslaAlicia Rodríguez Gascón
Mar 27, 2010·European Journal of Clinical Pharmacology·Roosmarijn F W De CockCatherijne A J Knibbe
Mar 24, 2016·Computer Methods and Programs in Biomedicine·Chayan AcharyaMats O Karlsson
Feb 5, 2016·The AAPS Journal·Adeline AngeliEmmanuelle Comets
Nov 12, 2015·Pharmaceutical Research·Francesco BellantiOscar Della Pasqua
May 31, 2016·Drug Metabolism and Pharmacokinetics·Wataru HonmaPhilip J Lowe
Jul 22, 2015·The Journal of Allergy and Clinical Immunology·Naïm BouazzaFabien Touzot
Nov 30, 2015·Drug Metabolism and Pharmacokinetics·Sebastian FrechenUwe Fuhr
Jun 13, 2015·Clinical Pharmacokinetics·Stéphanie LerouxUNKNOWN TINN (Treat Infections in NeoNates) and GRiP (Global Research in Paediatrics) Consortiums
Jul 4, 2015·British Journal of Clinical Pharmacology·Wei ZhaoEvelyne Jacqz-Aigrain
Sep 4, 2015·Anesthesia and Analgesia·Sabine J G M AhlersCatherijne A J Knibbe
Jun 9, 2011·British Journal of Clinical Pharmacology·Frantz FoissacSaïk Urien
Jun 23, 2011·British Journal of Clinical Pharmacology·David TernantGilles Paintaud
Apr 11, 2012·British Journal of Clinical Pharmacology·Naïm BouazzaJean-Marc Tréluyer
Dec 15, 2010·British Journal of Clinical Pharmacology·Jean-Marie ConilSylvie Saivin
Feb 16, 2011·Paediatric Anaesthesia·Brian J Anderson, Nick H G Holford

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