COMT and 5-HT1A-receptor genotypes potentially affect executive functions improvement after cognitive remediation in schizophrenia

Health Psychology and Behavioral Medicine
Marta BosiaRoberto Cavallaro

Abstract

Cognitive remediation therapy (CRT) has been proved to improve cognitive deficits in schizophrenia and to enhance functional outcomes of classical rehabilitation. However, CRT outcomes are heterogeneous and predictors of response are still unknown. Genetic variability, especially in the dopaminergic system, has been hypothesized to affect CRT. We previously reported that rs4680 of the catechol-O-methyltrasferase (COMT) influences improvements in executive functions in patients treated with CRT, but this result was not confirmed by other studies. Such inconsistent findings may depend, other than on clinical variables, also on other genes involved in cognition. Recent studies proved that serotonin 1A receptor (5-HT1A-R) regulates dopamine in the prefrontal cortex (PFC), and clinical works suggested a 5-HT1A-R role in cognition. We then analysed possible effects of COMT rs4680 and 5-HT1A-R rs6295 on CRT outcomes, taking into account also clinical and demographic factors. Eighty-six clinically stabilized schizophrenia patients treated with three months CRT were assessed with the Wisconsin Card Sorting Test, as a measure of executive functions, at enrolment and after CRT treatment, and underwent COMT and 5-HT1A-R genotyping. We foun...Continue Reading

References

Mar 1, 1995·Psychopharmacology·T Steckler, A Sahgal
Oct 2, 2001·The American Journal of Psychiatry·T SumiyoshiH Y Meltzer
Jun 14, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Cristina LorenziEnrico Smeraldi
Nov 18, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Llorenç Díaz-MataixPau Celada
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Llorenç Díaz-MataixFrancesc Artigas
Sep 5, 2006·Biological Psychiatry·Alessandro BertolinoTommaso Scarabino
Sep 11, 2009·Psychiatry Research·Roberto CavallaroEnrico Smeraldi
Mar 17, 2011·The American Journal of Psychiatry·Til WykesPál Czobor
Jun 21, 2011·Journal of Neural Transmission·Yoanna Arlina KurnianingsihKang Sim
Sep 1, 2011·Schizophrenia Bulletin·Til Wykes, Will D Spaulding

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Citations

Jun 11, 2019·The Australian and New Zealand Journal of Psychiatry·Maree P ReserSusan L Rossell
Feb 20, 2018·Neuropsychological Rehabilitation·Mariachiara BuonocoreMarta Bosia
Feb 16, 2019·Frontiers in Molecular Neuroscience·Xue WuBao-Jie Wang
Dec 20, 2020·Journal of Affective Disorders·Bruno BiagiantiPaolo Brambilla

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