COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study

PloS One
Aline S SampaioEurípedes Constantino Miguel

Abstract

Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. In an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design. Transmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed. OCD, broad and narrow phenotypes,were not associated with any of the investigated COMT and MAO-A polymorphisms. In addition, the analyses of gene-gene interaction did not show significant epistatic influences on pheno...Continue Reading

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Citations

Feb 7, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matea Nikolac PerkovicNela Pivac
Dec 22, 2015·Journal of Molecular Neuroscience : MN·Fernanda Brito Melo-FelippeFabiana Barzotti Kohlrausch
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Aug 30, 2019·Psychiatric Genetics·Gwyneth ZaiEdna Grünblatt
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman

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Methods Mentioned

BETA
Assay
PCR
genotyping

Software Mentioned

Genetic Power Calculator
SpectroTyper
Sequenom
Plink
SNPper
Assay Design
Haploview
Tagger

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