PMID: 26322144Sep 1, 2015Paper

COMT and OPRM1 Genotype Associations with Daily Knee Pain Variability and Activity Induced Pain

Scandinavian Journal of Pain
Lynn M MartireMartin J Sliwinski

Abstract

Osteoarthritis (OA) of the knee is a common and increasingly prevalent condition that is one of the primary causes of chronic pain. Staying physically active protects against disability from knee OA but is also very challenging. A critical but unexamined question is whether patients at greatest risk for becoming less active are those with a genetic predisposition for greater sensitivity to daily pain. We examined day-to-day variability in knee OA pain for patients with different variants of catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) single nucleotide polymorphisms (SNPs), and whether patients with a specific genotype experience more pain following daily physical activity. We predicted that patients having one or more copies of the Met158 allele of COMT rs4680 (A-A or A-G) and one or more copies of the Asp40 allele of OPRM1 rs1799971 (A-G or G-G) would show greater pain variability. We expected to see the same pattern for these SNPs with regard to moderation (i.e., exacerbation) of the activity-pain association. A total of 120 knee OA patients reported on their pain 3 times per day over 22 days using handheld computers, and wore an accelerometer to capture daily physical activity. Multilevel modeling was ...Continue Reading

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Citations

Oct 22, 2017·Pain Practice : the Official Journal of World Institute of Pain·Anne E OlesenAsbjørn M Drewes
Feb 12, 2021·Cellular Signalling·Rebecca SohnZsuzsa Jenei-Lanzl
Nov 19, 2020·European Journal of Clinical Pharmacology·Giovana M WeckwerthCarlos F Santos
May 4, 2021·Frontiers in Pharmacology·Giovana Maria WeckwerthCarlos Ferreira Santos
Jan 1, 2016·Scandinavian Journal of Pain·Pål Klepstad, Frank Skorpen

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