COMT genetic variation affects fear processing: psychophysiological evidence

Behavioral Neuroscience
Christian MontagMartin Reuter

Abstract

Emotional dysregulation is a core characteristic of many psychiatric diseases, including the anxiety disorders. Although heritable influences account for a significant degree of variation in risk for such disorders, relatively few candidate susceptibility factors have been identified. A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural responses to affective stimuli in healthy individuals. In 96 healthy women recruited from a sample of 800 participants according to genotype, the authors tested for an association between the DRD2/ANKK1 Taq Ia, the COMT Val158Met, and a psychophysiological measure of emotion processing, the acoustic affective startle reflex modulation (ASRM) paradigm, and found that COMT genotype significantly affected startle reflex modulation by aversive stimuli, with Met158 homozygotes exhibiting a markedly potentiated startle reflex compared with Val158 carriers. A trait measure of anxiety (Gray's Behavioral Inhibition System; J. A. Gray & N. McNaughton, 2000) was also associated with ASRM. The functional polymorphism in the dopamine D2 recept...Continue Reading

Citations

Mar 30, 2011·Journal of Neural Transmission·Diana ArmbrusterBurkhard Brocke
Jul 14, 2012·Current Pain and Headache Reports·Giancarlo LucchettiMario Fernando Prieto Peres
Feb 13, 2013·Development and Psychopathology·Elizabeth P HaydenDaniel N Klein
Jul 28, 2009·Cognitive Neuropsychiatry·Brita Elvevåg, Daniel R Weinberger
Mar 20, 2009·Journal of Toxicology and Environmental Health. Part a·Nicholas J HeyerJames S Woods
Oct 30, 2010·Social Cognitive and Affective Neuroscience·Martin ReuterChristian Montag
Apr 19, 2012·Addiction Biology·Arnt F A SchellekensRobbert-Jan Verkes
Apr 29, 2014·Neuroscience and Biobehavioral Reviews·Christian Montag, Martin Reuter
May 1, 2009·Cognitive, Affective & Behavioral Neuroscience·Martin J HerrmannAndreas J Fallgatter
May 10, 2013·Cognitive, Affective & Behavioral Neuroscience·Travis E BakerClay B Holroyd
Jun 5, 2015·Frontiers in Behavioral Neuroscience·Valentina MioneStefano Ferraina
Dec 14, 2011·The International Journal of Neuropsychopharmacology·Diana ArmbrusterClemens Kirschbaum
Jul 13, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Riederer
Apr 17, 2012·Psychoneuroendocrinology·Magdalena BuckertChristian J Fiebach
Apr 22, 2017·Pediatric Obesity·K K BostUNKNOWN STRONG Kids Team
Jan 21, 2017·Journal of Alzheimer's Disease : JAD·Lukas KunzChristian Montag
Sep 24, 2013·Psychological Science·Rebecca M ToddAdam K Anderson
Mar 9, 2012·Brain and Behavior·Andrea FeltenMartin Reuter
Aug 24, 2017·Depression and Anxiety·Jessica DeslauriersUNKNOWN Marine Resiliency Study Team
Aug 23, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V AlfimovaV E Golimbet
Oct 13, 2009·Psychophysiology·Paul PauliKlaus Peter Lesch
Apr 9, 2010·Psychophysiology·Christine L LarsonJordan S Robinson
Apr 2, 2014·Journal of the International Neuropsychological Society : JINS·Elisabeth M WeissIlona Papousek
Dec 17, 2014·Psychopharmacology·Katharina DomschkePeter Zwanzger
Oct 29, 2011·Evolutionary Anthropology·Brenda J Bradley, Richard R Lawler
Jun 19, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·B GohierS A Surguladze
Nov 16, 2010·CNS Neuroscience & Therapeutics·Dina CollipInez Myin-Germeys
Sep 18, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jennifer A SumnerKarestan C Koenen
Apr 27, 2017·Frontiers in Psychology·Christian Montag, Jaak Panksepp

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