PMID: 345280Feb 1, 1978

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives

Proceedings of the National Academy of Sciences of the United States of America
K UmezawaT Sugimura

Abstract

Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal enzymes. Harman also increased mutagenesis, althouth less so than norharman.

References

Nov 1, 1977·Nucleic Acids Research·K HayashiT Sugimura
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B N AmesH Bartsch

Citations

Jan 1, 1990·Applied Biochemistry and Biotechnology·H YanagisawaO Wada
Sep 1, 1988·Mutation Research·B Beije, L Möller
Oct 1, 1995·Mutation Research·C de Meester
Jun 1, 1981·Mutation Research·H KubinskiZ O Kubinski
Jul 1, 1980·Toxicology Letters·A HagiwaraN Ito
Nov 14, 1997·Mutation Research·J N PicadaJ A Henriques
Oct 1, 1984·Journal of Psychoactive Drugs·D J McKenna, G H Towers
Apr 1, 1983·Environmental Health Perspectives·P G ReuzelR Kroes
Mar 15, 1981·Biochemical Pharmacology·A D VazM J Griffin
Jan 15, 1979·Biochemical and Biophysical Research Communications·J F Remsen, P A Cerutti
Apr 1, 2005·The Journal of Toxicological Sciences·Toshio IchiharaTomoyuki Shirai
Jan 13, 2015·Food Chemistry·Elżbieta WojtowiczSylwia Mildner-Szkudlarz
Jun 1, 1979·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·H F Stich, A B Acton
Aug 1, 1979·CRC Critical Reviews in Toxicology·T Sugimura, M Nagao

Related Concepts

Plant alkaloid
Drug Augmentation
Fluorenes
Harmine
Microsomes, Liver
Clastogens
Salmonella typhimurium LT2
Acetylaminofluorene

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