PMID: 345280Feb 1, 1978

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives

Proceedings of the National Academy of Sciences of the United States of America
K UmezawaT Sugimura


Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal enzymes. Harman also increased mutagenesis, althouth less so than norharman.


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