PMID: 2484614Jul 1, 1989Paper

Comutagenicity and inhibition of DNA repair by metal ions in mammalian cells

Biological Trace Element Research
A Hartwig, D Beyersmann

Abstract

Mutagenic and/or carcinogenic metal compounds may act directly by interaction with DNA and/or indirectly by interference with genetic control and repair mechanisms. In a previous report, we investigated the mutagenicity and comutagenicity of nickel(II) in the V79 Chinese hamster HGPRT-assay. Our present findings demonstrate that like nickel(II), chromium(VI) and cadmium(II) are also comutagenic with UV. Furthermore, there is only a weak concordance with comutagenic effects observed in bacterial test systems. In the case of nickel(II), there is a good correlation between comutagenicity and inhibition of DNA repair, as determined by using the nucleoid sedimentation technique with HeLa cells. This inhibition may occur via replacement of other divalent ions essential in repair enzymes.

References

Oct 21, 1976·Nature·P R Cook, I A Brazell
Sep 1, 1986·Mutation Research·J S Dubins, J M LaVelle
Jan 1, 1984·Environmental Mutagenesis·J M LaVelle, C M Witmer

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Citations

Jan 1, 1996·Environmental and Molecular Mutagenesis·A Hartmann, G Speit
Dec 18, 2001·Journal of Biomedical Materials Research·Akiko YamamotoTakao Hanawa
Jan 1, 1993·Molecular Neurobiology·K S Rao
Jan 1, 1992·Pharmacology & Therapeutics·E T Snow
May 1, 1990·Mutation Research·A HartwigD Beyersmann
Feb 19, 1999·Mutation Research·P López-OrtalM C Gutiérrez-Ruiz
Mar 22, 2002·Mutation Research·Violaine VerougstraetePhilippe Hotz
Jun 29, 2011·Journal of Toxicology and Environmental Health. Part a·Naouale El-YamaniRicard Marcos
Nov 18, 2009·Biochemistry. Biokhimii︠a︡·I R GrinD O Zharkov
May 17, 2011·Biochemistry. Biokhimii︠a︡·I R Grin, D O Zharkov
Sep 1, 1994·Environmental Health Perspectives·A Hartwig
May 13, 2004·Photochemistry and Photobiology·Jin Kyu KimMarianna D Tkhabisimova
Jun 2, 2006·Critical Reviews in Toxicology·Max Costa, Catherine B Klein
Sep 26, 2009·Toxicology Mechanisms and Methods·Ayla CelikDilek Eke
Jan 1, 1995·Cancer Investigation·K S Kasprzak
Jul 20, 2011·Chemical Research in Toxicology·Anatoly Zhitkovich
Feb 1, 2006·Proteomics·Kirsten J Taylor-McCabeBabetta L Marrone
Jan 18, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Y KnöbelB L Pool-Zobel
Nov 20, 2002·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ruzica RozgajAleksandra Fucić
May 1, 1997·Toxicology and Applied Pharmacology·S LynnK Y Jan
Jun 4, 2011·Toxicology and Industrial Health·Dilek YilmazRahmi Bilaloglu
Mar 16, 2006·The Journal of Reproduction and Development·Toshitaka Horiuchi
Jul 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuonne KnöbelBeatrice Louise Pool-Zobel
Nov 1, 2007·Chemical Research in Toxicology·Konstantin Salnikow, Anatoly Zhitkovich

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