PMID: 3771872Aug 1, 1986Paper

Concanavalin A and Lens culinaris agglutinin binding patterns in normal and neoplastic sebaceous epithelium

Journal of Cutaneous Pathology
L Von KusterD E Ward

Abstract

Formalin-fixed, paraffin-embedded tissue sections of normal skin, sebaceous hyperplasia, nevus sebaceus, sebaceous adenoma, and sebaceous carcinoma were studied by means of biotinylated and FITC conjugated concanavalin A (Con A) and Lens culinaris agglutinin (LCA). At relatively high concentrations of these lectins, all cutaneous epithelial cells were stained. As the concentration of LCA was lowered, there was a corresponding decrease in the intensity of staining of all epithelial cells. With lowered concentrations of Con A, staining of sebaceous epithelium remained strongly positive, while staining of other epithelia decreased in a manner similar to that seen for LCA. These staining patterns were seen in normal and neoplastic tissues. Both Con A and LCA are known to bind to alpha-D-mannopyranosyl and alpha-D-glucopyranosyl residues of glycoproteins and glycolipids. The difference in staining of sebaceous epithelial cells by Con A and LCA suggests that the binding of these lectins is not determined strictly by the presence of alpha-D-mannopyranosyl or alpha-D-glucopyranosyl residues, but is modified by side-chain substitution on the monosaccharides and/or by the oligosaccharide which contains the particular monosaccharide. Whic...Continue Reading

References

Feb 1, 1973·The Journal of Investigative Dermatology·M L Nieland
Apr 1, 1974·The Journal of Investigative Dermatology·K HashimotoE Maeyens
Jan 1, 1974·International Review of Cytology·G L Nicolson
May 1, 1981·American Journal of Clinical Pathology·C J LouisT Sztynda
Jan 1, 1984·The Journal of Investigative Dermatology·M M BryskA A Hebert
Oct 1, 1984·Journal of the American Academy of Dermatology·A Miller, R J Barr
Aug 30, 1973·Biochimica Et Biophysica Acta·I J GoldsteinP A Gorin

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