PMID: 6980849Jan 1, 1982Paper

Concanavalin A-induced alteration of surface marker expression on murine T cells

International Journal of Immunopharmacology
I M Orme, F L Shand

Abstract

The activation of suppressor T cells by Concanavalin A (Con A) was characterized by changes in expression of T cell surface markers. Treatment of normal mouse spleen cells with monoclonal antibody to Ly-1 prior to activation with Con A consistently reduced the resulting suppressor cell activity as assayed by mixed culture with primed spleen cells responding to sheep erythrocytes. Addition of indomethacin to anti-Ly-1 depleted spleen cells together with Con A had no effect on the resulting suppressor cell activity, whereas its addition to normal spleen cells together with Con A significantly abrogated suppressor T cell induction. In contrast, treatment of normal spleen cells with anti-Ly-1 following 24h culture with Con A had no effect on resulting suppressor cell activity. Treatment of spleen cells either prior to or following culture with Con A with monoclonal antibody to Ly-2 completely abrogated suppressor T cell activity. Suppressor T cells activated by Con A were depleted significantly by fractionation on columns containing insolubilized histamine. In contrast, fractionation of normal spleen cells on histamine columns followed by culture with Con A had no effect on subsequent suppressor T cell induction. Furthermore, direc...Continue Reading

References

Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old
Nov 1, 1972·The Journal of Experimental Medicine·G M ShearerM Sela
May 29, 1980·The New England Journal of Medicine·R E RocklinK L Melmon
May 15, 1981·Cellular Immunology·A SchwartzR K Gershon
Jan 1, 1981·International Journal of Immunopharmacology·I M Orme, F L Shand
Aug 1, 1980·European Journal of Immunology·M VaeckP De Baetselier
May 1, 1981·The Journal of Experimental Medicine·B E LovelandI F McKenzie

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Citations

Nov 15, 1988·Physical Review. B, Condensed Matter·G J QuarlesS Lai
Jul 12, 2011·Integrative and Comparative Biology·James T Buchanan

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