PMID: 6159997May 1, 1980Paper

Concanavalin A reactivity pattern of human amniotic fluid AFP examined by crossed affino-immunoelectrophoresis. A definite test for neural tube defect?

Clinical Genetics
B Nørgaard-PedersenP Hindersson

Abstract

The percentage of alpha-fetoprotein (AFP) not reacting with concanavalin A (con A) was determined by crossed line affino-immunoelectrophoresis in amniotic fluid from 25 pregnancies with neural tube defects (NTD) and other fetal abnormalities giving rise to elevated AFP levels, and from 128 pregnancies with normal outcome. The percentage of con A non-reactive AFP is significantly lower in the presence of fetal abnormalities (mean 3.4%, range: 0.0-6.3, n = 25), compared to the percentage found in normal pregnancies (mean 17.2%, range: 6.6-35.8%, n = 128). In amniotic fluid samples from normal pregnancies, the percentage of con A non-reactive AFP in 84 cases with total AFP levels lying within the 95% reference interval was not significantly different from the percentage found in 44 cases with levels above the 95% reference interval. The percentage of non-reactive AFP in fetal serum and cerebrospinal fluid was of the same magnitude as found in amniotic fluids of pregnancies with fetal abnormalities. It is concluded that analysis of the percentage of con A non-reactive AFP by crossed line affino-immunoelectrophoresis is a simple, reliable and apparently diagnostic test for NTD and other abnormalities with leakage of fetal serum or c...Continue Reading

References

Sep 6, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·B Norgaard-Pedersen, N H Axelsen

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Citations

Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·R L VessellaP H Lange
Aug 1, 1981·The Australian & New Zealand Journal of Obstetrics & Gynaecology·D L HayJ G Grudzinskas
Aug 1, 1989·Electrophoresis·J Breborowicz, A Mackiewicz
Jul 1, 1991·Prenatal Diagnosis·K WiechenW Grote
Dec 1, 1990·Molecular Reproduction and Development·B A KeelS Cho
Jan 1, 1981·Prenatal Diagnosis·O S Jørgensen, B Nørgaard-Pedersen
Oct 14, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·K HuseG Kopperschläger

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