Concealed conduction effects in the atrium

IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society
Jan J ZebrowskiRafał Baranowski

Abstract

A one-dimensional (1-D) model of the atrium together with the sinoatrial (SA) and atrioventricular (AV) nodes is presented in this article. The two nodes are each modeled by 15-element, diffusively coupled, modified van der Pol oscillator chains, while the atrium tissue is represented by a 90-element chain of diffusively coupled FitzHugh-Nagumo (FHN) equations. The modified van der Pol oscillators are able to reproduce physiologically important properties, such as the refraction period, phase-sensitivity properties, and modes of change of the action potential frequency. The activity of both branches of the autonomous nervous system may be introduced into the model in a simplified way. The model enables the study of the effect of the magnitude of the action potential conduction rate in the nodes on interspike intervals (ISIs; equivalent of RR intervals) and explains the occurrence of RR-interval alternans in certain patients. The effect of breathing modulation of heart rate and of a single deep breath can also be modeled. Finally, concealed conduction effects in the atrium are studied, yielding results comparable with recorded heart rate variability data.

References

Jun 1, 1983·Circulation Research·J JalifeD C Michaels
Oct 26, 2006·Biomedizinische Technik. Biomedical Engineering·Krzysztof GrudzińskiRafal Baranowski
May 23, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A PortaP Van Leeuwen

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Citations

Feb 23, 2013·Journal of Clinical Monitoring and Computing·Piotr Podziemski, Jan J Zebrowski

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