PMID: 3753464Jun 1, 1986Paper

Concentration and relative molecular mass of hyaluronate in lymph and blood

The Biochemical Journal
A TengbladT C Laurent

Abstract

Human lymph was collected from patients with leaking lymph vessels after thoracic surgery. Ovine lymph was obtained from the mesenteric, lumbar, popliteal and prescapular lymph ducts by cannulation. The concentration of hyaluronate varied considerably (between 0.2 and 50 mg/l) and the highest concentrations were found in mesenteric lymph. The Mr of the polysaccharide showed a great polydispersity and variation between individuals and in different regions of the lymphatic system. High-Mr hyaluronate (greater than 10(6) was present in lymph both from man and sheep. Hyaluronate was also isolated by affinity chromatography in 70-80% yield from human serum and plasma obtained from healthy individuals and patients with rheumatoid arthritis and primary biliary cirrhosis. The weight (Mw)- and number (Mn)-average relative molecular masses were roughly the same in the three groups [(1.4-2.7) X 10(5) and (2.1-5.7) X 10(4) respectively]. The low Mr of hyaluronate in blood compared with that in lymph is explained by a preferential uptake of the large molecules by the liver endothelial cells.

Citations

Feb 26, 1999·The Journal of Cell Biology·S BanerjiD G Jackson
Jan 1, 1990·Connective Tissue Research·A Engström-Laurent, S Hellström
Aug 1, 1995·Journal of Cellular Physiology·U M AgrenR Tammi
Jan 1, 1994·Progress in Histochemistry and Cytochemistry·R TammiM Tammi
Mar 2, 2010·Journal of Pharmaceutical and Biomedical Analysis·D CozikovaV Velebny
Jan 23, 2009·Veterinary Immunology and Immunopathology·Hung-Hsun YenJean-Pierre Y Scheerlinck
Nov 26, 1999·The Journal of Investigative Dermatology·T J BrownJ R Fraser
Oct 19, 2011·International Journal of Rheumatic Diseases·Yoshiko SasakiTakashi Sawai
Mar 1, 1983·Experimental Cell Research·S ErikssonB Smedsrød
Mar 1, 1991·The Journal of Surgical Research·J J FerraraA E Taylor
Nov 1, 1988·Acta Physiologica Scandinavica·R K ReedT C Laurent
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·T W KnutsonL Knutson
Jun 18, 2015·Frontiers in Immunology·Mary K CowmanEva A Turley
Jun 2, 2015·Frontiers in Immunology·James MonslowEllen Puré
Jan 13, 2015·Analytical Biochemistry·Han YuanMary K Cowman
Jan 1, 2010·Mediators of Inflammation·Barbora SafrankovaLukas Kubala
Sep 1, 1996·Acta Neurologica Scandinavica·U B LaurentK Lilja
Aug 5, 2003·Reproduction, Fertility, and Development·Paisan TienthaiHeriberto Rodriguez-Martinez
Feb 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P CampbellL Rodén
Nov 1, 1994·Agents and Actions·A Ialenti, M Di Rosa
Mar 22, 2014·Molecular Pharmaceutics·Madalena MartinsArtur Cavaco-Paulo
Sep 1, 1989·The Annals of Otology, Rhinology, and Laryngology·C LaurentK Lilja
Apr 1, 1992·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·L HagbergK Ohlsson
Jan 5, 2018·Glycobiology·Xiayun HuangMary K Cowman
Jul 25, 2000·European Journal of Clinical Investigation·U LindqvistB Långström
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ShimizuR E Falk
Mar 1, 1987·The British Journal of Dermatology·A LundinA Tengblad
Jun 5, 2007·Nature Protocols·Qijie ChenToshihiro Mitaka
Jan 1, 1995·Journal of Gastroenterology and Hepatology·B Smedsrød
Jul 1, 1991·Gut·B Gerdin, R Hällgren
Sep 1, 1994·European Journal of Clinical Investigation·L LebelB Gerdin
Oct 1, 1993·Acta Physiologica Scandinavica·G Ostgaard, R K Reed
Aug 30, 2003·Oncogene·Richard Kolesnick, Zvi Fuks
Oct 22, 2005·Journal of Internal Medicine·J R E Fraser, P R Gibson
Jul 10, 2002·Clinical Pharmacokinetics·Ulla LindqvistHans Lundqvist

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