PMID: 6110599Mar 1, 1981Paper

Concentration and secretion of gastric somatostatin in streptozotocin-diabetic rats

Diabetes
T ChibaT Fujita

Abstract

Both the release and the content of gastric somatostatin were investigated in streptozotocin-diabetic rats. Fundic and antral somatostatin contents were both increased in streptozotocin-diabetic rats compared with control animals. Basal somatostatin levels in the perfusates of streptozotocin-treated animals were not significantly different from those of the control animals. However, the peak values of somatostatin release induced by 5 x 10(-9) M glucagon in the diabetic animals were significantly higher than those of the controls. These results lead us to conclude that a hyperfunctioning state of the gastric D-Cells exists in hypoinsulinemic diabetes.

Citations

Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H KoopR Arnold
Jan 1, 1984·The Journal of Clinical Investigation·G J Taborsky, J W Ensinck
Aug 1, 1995·Histochemistry and Cell Biology·L I LarssonD M Hougaard
Apr 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·O SegersG Somers
Feb 1, 1986·Metabolism: Clinical and Experimental·A VerrilloR Golia

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