Concentration and volume effects in thermochemical ablation in vivo: results in a porcine model

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Erik N K CressmanJohn C Bischof

Abstract

To explore the effects of volume and concentration in thermochemical ablation using an in vivo porcine model. Twelve swine 60-75 kg were used in this institutionally approved study. A needle design prototype coaxial device for reagent injections and a thermocouple were inserted into surgically exposed liver. Simultaneously, an acid and base (acetic acid and NaOH) were injected at 4 mL/min based on a 3 × 3 matrix with concentration (5, 10, and 15 mol/L) and volume on the axes (total volumes of 1, 2, and 4 mL). Three animals (centre grid position) strengthened the statistical analysis. Each animal received four identical injections (total 48). Temperatures and heart rate were recorded. Livers were formalin-fixed after sacrifice. After sectioning, coagulation zones were analysed by two observers. Area and slice thickness were used to calculate the volume, surface area, and sphericity for each treatment. Coagulation volumes ranged from 2.95 ± 0.29 to 14.72 ± 1.42 mL with a maximum of 18.3 mL. Highest peak temperature was 105°C with temperatures ranging 43.5 ± 2.6°C to 91.0 ± 6.5°C. There was no association between conditions and sphericity or heart rate. The method can be used successfully to ablate tissue in vivo. By neutralising ...Continue Reading

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Citations

Jan 15, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Erik N K Cressman, David A Jahangir
Aug 24, 2013·Journal of Healthcare Engineering·Zhong-Shan Deng, Jing Liu
Jul 17, 2018·PloS One·Erik N K CressmanNiloofar Karbasian
Oct 12, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·David FuentesErik N K Cressman
Jun 7, 2018·Cardiovascular and Interventional Radiology·Erik N K Cressman, Chunxiao Guo

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