Concentration dependence of quaternary ammonium monomer on the design of high-performance bioactive composite for root caries restorations

Dental Materials : Official Publication of the Academy of Dental Materials
Abdulrahman A BalhaddadMary Anne S Melo

Abstract

Dental plaque build-up on the cervical area adjacent to gingival margins is a trigger factor for secondary caries around restored root caries lesions. Dimethylaminohexadecyl methacrylate (DMAHDM) and amorphous calcium phosphate nanoparticles (NACP) impart anti-caries effect by reducing the bacterial growth and releasing high concentrations of calcium and phosphate ions, respectively. The present study explored the optimization and formulation of dental composite with increased concentration of DMAHDM combined with NACP and its effect on mechanical behavior and antibacterial response. DMAHDM was incorporated into dental composite formulation at 3% and 5% with 20% NACP fillers. Mechanical properties were assessed by flexural strength and elastic modulus. The cationic charge density of the samples was determined using fluorescein staining assay. A human saliva-derived microcosm biofilm model was used to assess antibacterial response via colony-forming units, metabolic activities, lactic acid production, and live/dead assay. Surface roughness was measured after 48h-biofilm formation. The viability of human saliva microcosm biofilms was DMAHDM concentration-dependent, where all the microbiological assays were substantially reduced i...Continue Reading

References

Jan 1, 1987·Archives of Oral Biology·P M HoppenbrouwersJ M Borggreven
Mar 1, 1997·Journal of Dental Research·S ImazatoJ F McCabe
Jun 5, 1998·Journal of Dentistry·J S Rees, P H Jacobsen
Jul 13, 2005·Dental Materials : Official Publication of the Academy of Dental Materials·M PeumansB Van Meerbeek
Sep 5, 2009·Advances in Applied Microbiology·Andrew J McBain
Apr 10, 2010·Journal of Applied Oral Science : Revista FOB·Hanadi Yousif Marghalani
Nov 26, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Jack L Ferracane
Mar 8, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Jun Zhao, Dong Xie
Apr 20, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jennifer L MoreauHockin H K Xu
Apr 26, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Hockin H K XuLaurence C Chow
Nov 1, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Joseph M AntonucciNancy J Lin
Feb 7, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Lei ChengXuedong Zhou
Nov 13, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Mary Anne S MeloHockin H K Xu
Jun 19, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Chenchen ZhouHockin H K Xu
Jul 3, 2013·Trends in Biotechnology·Mary A S MeloLidiany K A Rodrigues
Aug 21, 2013·Journal of Dental Research·F LiH H K Xu
Dec 6, 2014·Journal of Dentistry·Ning ZhangHockin H K Xu
Mar 17, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·David C Watts
Sep 28, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Ivana NedeljkovicKirsten L Van Landuyt
Jan 9, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Ling ZhangHockin H K Xu
Jul 28, 2016·Caries Research·Nobuhiro Takahashi, Bente Nyvad
Jul 2, 2017·Acta Biomaterialia·Marieke van de LagemaatYijin Ren
Jun 25, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Yuncong LiHockin H K Xu
Oct 3, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Yousif A Al-DulaijanHockin H K Xu
Nov 15, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Haohao WangHockin H K Xu
Mar 3, 2019·Journal of Dentistry·Bashayer H BarasHockin H K Xu
Mar 6, 2019·Restorative Dentistry & Endodontics·Abdulrahman A BalhaddadRichard L Gregory
Mar 18, 2019·Dental Materials : Official Publication of the Academy of Dental Materials·Lin WangHockin H K Xu

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Citations

Jul 31, 2020·Journal of Functional Biomaterials·Nikos N LygidakisAnne M Young
Oct 21, 2020·International Journal of Molecular Sciences·Abdulrahman A BalhaddadMary Anne S Melo
Nov 26, 2020·Gerodontology·Mohammed S AlQraneiMary A S Melo
Nov 5, 2020·Polymers·Marta Chrószcz, Izabela Barszczewska-Rybarek
Jan 24, 2021·Journal of Biomaterials Science. Polymer Edition·Ghalia Bhadila Xu
May 18, 2021·The Japanese Dental Science Review·Francisca Jennifer Duarte de OliveiraDiana Ferreira Gadelha de Araújo
Jun 26, 2021·Journal of Dental Research·A A BalhaddadM A S Melo

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