PMID: 1209792Dec 30, 1975Paper

Concentration of antibiotics in renal interstitial fluid: an experimental model

Urological Research
H U EickenbergL Scharfenberger

Abstract

In a new canine experimental model the time concentration relationship of cephalothin in serum, urine, soft tissue interstitial fluid (STIF) and renal interstitial fluid (RIF) were compared simultaneously. Antibiotic concentration in RIF was less than urinary levels but exceeded the serum concentration. Urinary antibiotic concentration does not necessarily reflect concentration in the renal interstitium. This model helps to understand the basic pharmacokinetics of antibiotics in the renal interstitium where pyelonephritis occurs.

Citations

Oct 1, 1976·Antimicrobial Agents and Chemotherapy·N G WatermanL Scharfenberger
Aug 1, 1977·Antimicrobial Agents and Chemotherapy·A BaumuellerP O Madsen
Oct 1, 1978·Antimicrobial Agents and Chemotherapy·N G Waterman, L F Scharfenberger

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