Concentration of antipneumococcal antibodies as a serological correlate of protection: an application to acute otitis media

The Journal of Infectious Diseases
Jukka T JokinenM Helena Käyhty

Abstract

For the licensing of new pneumococcal vaccines, it is vital to be able to predict their protective efficacy on the basis of immunogenicity. However, the serological correlates of protection have not been established for pneumococcal diseases. A total of 1666 children were immunized with the pneumococcal conjugate vaccine. Acute otitis media (AOM) events were identified, and middle-ear fluid was cultured for pneumococci. The association between the concentration of antibodies against serotypes 6B, 19F, and 23F and the risk of AOM caused by the homologous serotypes or by the cross-reactive serotype 6A was assessed. An association model was used to predict efficacy at different geometric mean concentrations (GMCs). An association between antibody concentration and risk of AOM was found, but with large differences between serotypes. On the basis of the association, the predicted efficacy for 19F was negligible up to the highest GMC tested. In contrast, 6B was found to be highly efficacious (>65%) at a GMC of 0.5 microg/mL. The results challenge the view that a new vaccine candidate should always induce antibody concentrations that are not inferior to those produced by the licensed vaccine. Furthermore, the differences between serot...Continue Reading

Citations

May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Catherine McEllistremEllen R Wald
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Warren E Regelmann
Feb 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stanley A Plotkin
Jun 24, 2009·The Pediatric Infectious Disease Journal·Andrew JardinePeter B McIntyre
Dec 16, 2009·The Pediatric Infectious Disease Journal·Stephen I Pelton, Eugene Leibovitz
Jul 28, 2010·The Pediatric Infectious Disease Journal·Noga Givon-LaviRon Dagan
Mar 2, 2013·BMC Medical Research Methodology·Xuan ChenAndrew J Dunning
Oct 30, 2009·Expert Review of Vaccines·Roman Prymula, Lode Schuerman
Oct 2, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yen-Hsin KungHsin Chi
Aug 1, 2006·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Pei-Lan ShaoLi-Min Huang
Jul 21, 2005·Vaccine·Manuela MenzelLoems Ziegler-Heitbrock
May 15, 2015·Human Vaccines & Immunotherapeutics·Nicola Principi, Susanna Esposito
Oct 14, 2014·Frontiers in Immunology·Rohan AmeratungaSee-Tarn Woon
Mar 8, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Claire DendleWilliam R Mulley
Oct 27, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Merryn VoyseyAndrew J Pollard
Oct 1, 2014·Expert Review of Vaccines·William P HausdorffRichard A Adegbola
Sep 23, 2006·Expert Review of Vaccines·Allan W Cripps, Diana C Otczyk
Dec 22, 2006·Expert Review of Vaccines·Helena KäyhtyHelena Mäkelä
Feb 24, 2019·Archives of Disease in Childhood·Petra ZimmermannNigel Curtis
Aug 3, 2019·Future Microbiology·Susanna Esposito, Nicola Principi
Aug 8, 2017·Expert Review of Vaccines·Raul IsturizLuis Jodar
Jan 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ron DaganDaniel A Scott
Nov 8, 2013·Expert Review of Vaccines·Jan T PoolmanGermie P J M van den Dobbelsteen
Nov 14, 2019·Clinical Reviews in Allergy & Immunology·Rohan Ameratunga, See-Tarn Woon
Mar 26, 2011·Expert Review of Vaccines·Bernard Fritzell, Mark A Fletcher

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