Concentration of moxifloxacin in plasma and tonsillar tissue after multiple administration in adult patients

The Journal of Antimicrobial Chemotherapy
Silvano EspositoAndrea Novelli

Abstract

The antibacterial spectrum of moxifloxacin includes all the major respiratory pathogens, and its pharmacokinetics demonstrate high peak concentrations in plasma as well as at respiratory sites. Nevertheless, tonsillar tissue concentrations have never been investigated. In this study we determined the moxifloxacin concentrations in plasma and tonsillar tissue after the administration of three doses of moxifloxacin 400 mg to adult patients with chronic or recurrent tonsillitis undergoing tonsillectomy. This was an uncontrolled, open-label, randomized, parallel group study including 35 patients assigned randomly to five groups of 7 patients each, depending on the time between the last dose of moxifloxacin and plasma and tissue sampling. Moxifloxacin was given orally once daily for 3 days; its concentrations were measured using a validated HPLC assay and fluorescence detection. Each sample was analysed twice and the mean value obtained used for the statistical analysis. Pharmacokinetic data were analysed by presenting descriptive statistics of moxifloxacin concentrations in plasma and tonsillar tissue. C(max) occurred at 3 h in tonsillar tissue (mean 8.96 mg/L) and in plasma (mean 3.20 mg/L), the tissue/plasma concentration ratios ...Continue Reading

References

Feb 1, 1997·Clinical Pharmacokinetics·D N Fish, A T Chow
Mar 5, 2004·The Annals of Otology, Rhinology, and Laryngology·Paulo Borges DinisJosé Guimarães Morais
Apr 2, 2004·The Journal of Antimicrobial Chemotherapy·Martin WirtzHelmut Friess

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Citations

Jul 7, 2011·The Journal of Antimicrobial Chemotherapy·Martin G KeesThomas Horbach
Nov 5, 2013·Journal of Women's Health·Elisa Chilet-RosellMa Angeles Pardo
Aug 18, 2009·Expert Review of Anti-infective Therapy·Olaf Burkhardt, Tobias Welte
Jan 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·C VilaltaL Fraile

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