PMID: 3762427Sep 1, 1986Paper

Concentration of plasma albumin in its accessible space in postmortem human dermis

Microvascular Research
J L BertJ M Mathieson

Abstract

This study was designed to measure the effective concentration of plasma albumin in the interstitial space of human dermis. Discs of tissue taken postmortem from four donors have been separately analyzed for their content of plasma albumin and equilibrated with 125I-labeled monomeric plasma albumin in a specially designed cell which limited tissue swelling. The equilibrated discs and their surrounding fluid were assayed for radioactivity and the tissue space accessible to albumin was calculated after correction for swelling. The albumin content of serum was also measured. The concentration of albumin in the accessible space of the tissue ranged from 0.45 to 0.93 that in serum, averaging 0.68. The fraction of the total interstitial fluid accessible to albumin averaged, for three normal dermises, 0.35 and for an overhydrated specimen, 0.51. Thus, the effect of volume exclusion should be considered in measurements of the concentrations of plasma proteins in tissue.

References

Jul 1, 1979·Microvascular Research·C A Wiederhielm
Sep 1, 1979·Microvascular Research·J R Fox, H Wayland
Jul 1, 1978·Microvascular Research·P D Watson, F S Grodins
Feb 8, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·A R Bradwell, D Burnett
Sep 1, 1986·Microvascular Research·J M MathiesonJ L Bert
Jun 1, 1972·The Journal of Investigative Dermatology·R H Pearce, B J Grimmer
Jan 1, 1973·Scandinavian Journal of Immunology. Supplement·B Weeke
Dec 1, 1970·Clinical Science·J KatzA L Sellers
Dec 1, 1980·The Biochemical Journal·J L BertS J Warner
Nov 1, 1963·Canadian Journal of Biochemistry and Physiology·P R SWEENYH G VANCE

❮ Previous
Next ❯

Citations

Sep 12, 2001·Magnetic Resonance Imaging·A S Dzik-JuraszI J Rowland
Aug 26, 2003·The Journal of Physiology·Christina C GyengeHelge Wiig
Dec 12, 2012·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·G A Martos-MorenoJ J Kopchick
Jun 10, 2010·Journal of Pharmaceutical Sciences·Rania Ibrahim, Gerald B Kasting
May 27, 2003·The Journal of Physiology·Helge WiigJoel L Bert
Oct 8, 2005·The Journal of Physiology·Helge WiigJoel L Bert
Sep 1, 1986·Microvascular Research·J M MathiesonJ L Bert
Jun 25, 1998·Disability and Rehabilitation·J L Murphy, S A Wootton
Jul 31, 2020·Expert Opinion on Drug Metabolism & Toxicology·Diego Pilati, Kenneth A Howard
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H WiigO Tenstad
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Helge WiigOlav Tenstad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.