PMID: 20648764Jan 1, 2009Paper

Concentration of soluble Fas receptor (sFas) in serum of patients with ST-segment elevation myocardial infarction

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Aleksandra Mielczarek-PalaczJoanna Podsiadło

Abstract

Impairments ofapoptosis process, called programmed cell death, are the basis of pathogenesis of cardiovascular disease, including myocardial infarction. The aim of our study was to evaluated concentration of soluble receptor Fas (sFas)--marker ofapoptosis--in serum of patients with ST-segment elevation myocardial infarction. The study group consisted of 70 patients aged 42 to 75 (mean 58.3 +/- 7.6 years) with the confirmed first episode of the ST-segment elevation myocardial infarction. The analyzed material was blood obtained from patients at fourth time: I. the time of admission, II. after 12 hour, III. after 24 hour and IV. on 5th day. The concentrations of the serum sFas was performed with the use of the immunoenzymatic method ELISA using commercial kits Human sAPO-1/Fas ELISA, Bender MedSystems Diagnostics GmbH, Austria. The sensitivity of the kit was 13.2 pg/ml. Concentration of sFas at a time of admission was the highest, among 50.30 and 68.70 pg/ml (mean: 58.73 +/- 5.63 pg/ml). After 12 h, the studied parameter level was significantly lower in comparison with sFas level in admission (p < 0.001), after 24 h (p < 0.0001) and on discharge from hospital (p < 0.001). In patients with myocardial infarction were observed inten...Continue Reading

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis