Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with malignant bone tumors

Medical and Pediatric Oncology
G HolzerK Trieb

Abstract

Vascular endothelial growth factor (VEGF) is recognized as an important stimulator of angiogenesis. Formation of new blood vessels by angiogenic factors occurs in many biological processes, both physiological and pathological, among others in growth of primary solid malignant tumors and metastasis. This implies that the inhibition of angiogenic factors like VEGF would result in a suppression of tumor growth and metastasis formation. The aim of the present study was to compare preoperative serum VEGF levels of patients having malignant bone tumors with healthy controls to identify serum VEGF levels as a tumor marker. Blood sera from patients with high-grade osteosarcoma (n = 17), chondrosarcoma (n = 4) and Ewing sarcoma (n = 6) were taken at the time of diagnosis before biopsy and compared with sera from 129 healthy persons. To measure VEGF levels in serum, a commercially available ELISA was used (Quantikine Human VEGF Immunoassay; R&D Systems). The observed geometric mean VEGF levels and 95% confidence intervals are 232.0 pg ml(-1) (168.9-318.5) for patients with high-grade osteosarcoma, 325.5 pg ml(-1) (169.3-625.8) for patients with chondrosarcoma, 484.3 pg ml(-1) (284.0-826.0) for patients with Ewing sarcoma, as compared to ...Continue Reading

References

Apr 1, 1992·The Journal of Experimental Medicine·D J PeacockE Brahn
Jul 1, 1986·Endocrinology·H L GuentherN Sorgente
Jun 1, 1994·The Journal of Clinical Investigation·S HaradaS B Rodan
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D S WangK Sato
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Ferrara
Jan 1, 1997·Investigational New Drugs·M Nguyen
Jul 17, 1998·The American Journal of Pathology·P SalvenH Joensuu
Aug 1, 1960·The Journal of Bone and Joint Surgery. British Volume·J Trueta, V P Amato

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Citations

Aug 19, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Weiguo XuChengla Yi
May 31, 2012·International Orthopaedics·Ramakant KumarLaxman Rijal
Sep 28, 2012·International Orthopaedics·Shishir RastogiMehar C Sharma
Oct 26, 2005·Current Treatment Options in Oncology·Nancy R McAllister, Stephen L Lessnick
May 17, 2012·Clinical Sarcoma Research·Annmeik M van MaldegemAndrew B Hassan
Nov 2, 2011·The Oncologist·Julia Glade BenderElizabeth Fox
Feb 24, 2011·Expert Review of Anticancer Therapy·Danielle G SmithSusan A Burchill
Apr 12, 2008·Expert Review of Anticancer Therapy·Patrick J Leavey, Anderson B Collier
Feb 25, 2009·Expert Opinion on Investigational Drugs·Rachael WindsorJeremy Whelan
May 12, 2009·Archives of Medical Research·Zhen-Yu BianTing-Ting Tang
Feb 25, 2005·American Journal of Reproductive Immunology : AJRI·Derrick LaneSubbi P Mathur
Jun 10, 2008·International Journal of Cancer. Journal International Du Cancer·Krishna ReddyEugenie S Kleinerman
Mar 7, 2006·Journal of Pediatric Surgery·Danko MikulićSven Seiwerth
Mar 13, 2014·Critical Reviews in Oncology/hematology·Yvonne M H Versleijen-JonkersWinette T A van der Graaf
Jul 21, 2011·The American Journal of Pathology·Toshifumi FujiwaraYukihide Iwamoto
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra S McAllister, Robert A Weinberg
Aug 2, 2014·Nature Cell Biology·Sandra S McAllister, Robert A Weinberg
Feb 1, 2007·Cancer·Steven DuBois, George Demetri
May 23, 2019·Investigative Ophthalmology & Visual Science·Kyu-Yeon HanDimitri T Azar
Nov 4, 2017·Calcified Tissue International·Thomas R CoxRobin M H Rumney
Jun 2, 2009·The Journal of Bone and Joint Surgery. British Volume·M KayaT Yamashita
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruno FuchsRalf Janknecht
Dec 17, 2005·Cancer Research·Daisy W J van der SchaftArjan W Griffioen
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hui GuanEugenie S Kleinerman
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Surita DalalSusan A Burchill

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