Concentration of vitamin B6 and activities of enzymes of B6 metabolism in the blood of alcoholic and nonalcoholic men

Alcoholism, Clinical and Experimental Research
M L FondaM W Pendleton

Abstract

The purpose of this study was to compare concentrations of vitamin B6 compounds and the activities of enzymes that synthesize or catabolize pyridoxal 5'-phosphate in the plasma and erythrocytes of nonalcoholic and alcoholic subjects. Blood was obtained from male nonalcoholics and chronic alcoholics with minimal liver damage and normal hematology. Plasma, erythrocyte, and urinary B6 compounds were analyzed by high performance liquid chromatography, and pyridoxal phosphate was also measured enzymatically. Erythrocyte pyridoxine kinase and pyridoxine phosphate oxidase and erythrocyte and plasma pyridoxine phosphate phosphatases were assayed. Plasma pyridoxal phosphate concentration was significantly lower in the alcoholics (31.3 +/- 3.6 nmol/liter) than in the nonalcoholics (58.7 +/- 7.5 nmol/liter). The concentrations of the other B6 compounds in plasma, erythrocytes, and urine were not different in the two groups. Plasma alkaline pyridoxine phosphate phosphatase activity was significantly higher in the alcoholics (4.05 +/- 0.36 nmol/(h.mg] than in the nonalcoholics (3.01 +/- 0.18 nmol/(h.mg]. The activities of erythrocyte kinase, oxidase, and phosphatases were not significantly different in the two groups. The relationship of pl...Continue Reading

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Citations

Sep 8, 2010·Journal of Gastrointestinal Cancer·David H Van Thiel, Guiliano Ramadori
Dec 1, 1993·Alcoholism, Clinical and Experimental Research·M L Fonda
Apr 25, 2000·Alcoholism, Clinical and Experimental Research·F StickelJ B Mason
Aug 15, 2000·Annual Review of Nutrition·C S Lieber
Aug 12, 2009·Circulation·John H PageEric B Rimm
Jun 25, 2005·Alcoholism, Clinical and Experimental Research·Carmen BlascoJuan Rodés
Feb 24, 2001·Critical Reviews in Clinical Laboratory Sciences·C S Lieber
Aug 28, 2003·Alimentary Pharmacology & Therapeutics·F StickelH K Seitz
Mar 28, 2019·International Journal of Biological Macromolecules·Hyo Je ChoBeom Sik Kang
Mar 15, 2005·Clinics in Liver Disease·Carroll M Leevy, Serban A Moroianu

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