Concentrations in serum and distribution in tissue of free and liposomal amphotericin B in rats during continuous intralipid infusion.

Antimicrobial Agents and Chemotherapy
Kishor M WasanG López-Berestein

Abstract

The influences of Intralipid (IL) and 0.45% normal-saline infusions on the concentration in serum and distribution in tissue of amphotericin B (AmpB) and liposomal amphotericin B (L-AmpB) in rats were compared. In animals receiving a continuous IL infusion, concentrations of AmpB in kidneys and lungs were significantly higher, but the concentration of AmpB in serum was significantly lower in animals administered AmpB versus those given L-AmpB. In animals receiving a continuous normal-saline infusion concentrations of AmpB in kidneys and the spleen were significantly higher, but the concentration of AmpB in serum was significantly lower in animals administered AmpB versus those given L-AmpB. These results suggest that the increased total serum cholesterol and high-density lipoprotein cholesterol during the IL infusion decreased the clearance of AmpB from the bloodstream and decreased the L-AmpB concentration in the kidney and lung.

References

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Feb 1, 1993·Antimicrobial Agents and Chemotherapy·K M WasanG Lopez-Berestein

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Citations

Jan 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K M Wasan, G Lopez-Berestein
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Karen BartlettKishor M Wasan
Oct 20, 2004·Drug Development and Industrial Pharmacy·Verica RisovicKishor M Wasan
Apr 21, 1998·Journal of Pharmaceutical Sciences·K M Wasan, S M Cassidy
Aug 15, 1994·Annals of the New York Academy of Sciences·K M Wasan, G Lopez-Berestein
Aug 1, 1997·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Pascal ChavanetHenri Portier
Oct 5, 2016·Antimicrobial Agents and Chemotherapy·Jodi M LestnerWilliam W Hope
Jan 8, 2014·Clinical Microbiology Reviews·Timothy FeltonWilliam W Hope
Apr 1, 1996·The Annals of Pharmacotherapy·J D Cleary
May 16, 2018·Antimicrobial Agents and Chemotherapy·Alicia López-SánchezSusana Torrado

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