Concentrations of copper, zinc, manganese, rubidium, and magnesium in thoracic empyemata and corresponding sera

Biological Trace Element Research
W DomejJohanna Lang

Abstract

In this study, a number of selected trace elements and clinically relevant parameters were compared between thoracic empyemata and the corresponding sera for a better understanding of the trace element distribution between these two compartments. Serumempyema pairs were obtained from 13 patients and quantified for selected and essential trace elements, namely copper (Cu), zinc (Zn), manganese (Mn), rubidium (Rb), and magnesium (Mg), by inductively coupled plasma-mass spectrometry (ICP-MS). In addition, the concentrations of the following clinical laboratory parameters were analyzed by standard methods: total protein, leukocyte count, lactate dehydrogenase, glucose, pH, and the C-reactive protein. Individual concentrations of the elements determined in the empyemata were frequently higher than in pleural effusions of any other benign or malignant condition except for Cu. Serum Cu exceeded the normal range (600-1400 microg/kg) in 6 out of 13 patients (median 1410 microg/kg). In the empyemata, Zn concentrations (median 2000 microg/kg) were characteristically higher than in the sera (median 450 microg/kg) and exceeded the upper limit for serum (1200 microg/kg) in 8 of the 13 patients. Manganese concentrations in the empyemata (medi...Continue Reading

Citations

Feb 17, 2015·Neurochemistry International·Daniel DahlbergBjørnar Hassel
Jun 24, 2017·Biological Trace Element Research·Kang-Yun LeeShu-Chuan Ho
Feb 15, 2019·International Journal of Molecular Sciences·Belén Callejón-LeblicTamara García-Barrera
Jan 10, 2021·Seminars in Cell & Developmental Biology·Qian WuFudi Wang
May 13, 2021·Health Science Reports·Deirdre B FitzgeraldY C Gary Lee

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