PMID: 16521941Mar 9, 2006Paper

Concentrations of cotinine in serum and urine of smoking pregnant women and in placenta and umbilical cord blood

Przegla̧d lekarski
Teresa Laskowska-KlitaJerzy Leibschang

Abstract

Concentration of cotinine, the major metabolite of nicotine in body fluids, is commonly accepted as the method which may better reflect tobacco smoke exposure than the questionnaire. In order to assess adverse fetal health effects caused by cigarette smoking it is important to study the relation between maternal and fetal exposure to tobacco smoke compounds. We determined serum and urine cotinine levels in the course of pregnancy, as well as its concentration in placenta and umbilical cord blood. In group of smoking women serum cotinine concentration was high (above 1050 microg/l) and stable in I, II and III trimester. It was correlated with amount of cotinine (about 2000 microg/g creatinine) in urine (r=0.8; p<0.0001). In serum of umbilical cord blood level of cotinine was half (range: 300-600 microg/ I) of that observed in maternal blood and was correlated with it (r=0.67; p<0.01). In placenta of smoking women mean concentration of cotinine was 57.5 ng/g tissue. In serum of non-smoking pregnant women and in blood of their babies we found trace amount of cotinine in 50% of mothers and 30% of infants. In this group concentration of cotinine in urine as well as in placenta was not detectable. The obtained results indicate that a...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Irina StepanovIgor Mardari
Environmental Research
Sungroul KimPatrick N Breysse
Journal of Exposure Analysis and Environmental Epidemiology
Gerhard SchererHeidrun Behrendt
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Carolyn L AbitbolGastón Zilleruelo
© 2021 Meta ULC. All rights reserved