Concentrations of highly sensitive cardiac troponin-I predict poor cardiovascular outcomes and adverse remodeling in chronic heart failure

Journal of Cardiovascular Translational Research
Shweta R MotiwalaJames L Januzzi

Abstract

Highly sensitive troponin (hsTn) assays may predict cardiovascular (CV) events and left ventricular (LV) remodeling in patients with heart failure (HF). In this study, 99 subjects with LV systolic dysfunction (LVSD) were followed 10 ± 3 months with serial measurement of hsTnI by a novel method. hsTnI was detectable in all subjects and was above the 99th percentile of a normal population in 56.7 %. Supramedian baseline hsTnI concentration was associated with higher-risk clinical features and shorter time-to-first event (p = 0.008). Across serial measurements, more time spent ≤ 10.9 pg/mL was associated with a lower CV event rate after adjustment (odds ratio (OR) = 0.81; p = 0.008); rising hsTnI also predicted progressive LV remodeling. In conclusion, hsTnI detected significant myocardial necrosis in a majority of patients with chronic HF due to LVSD and when measured serially, provided independent risk information for poor CV outcomes and deleterious LV remodeling.

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References

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Citations

Aug 19, 2015·Current Heart Failure Reports·Parul U GandhiTariq Ahmad
Jun 7, 2016·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Larisa G TereshchenkoFrederick K Korley
Oct 21, 2016·Current Heart Failure Reports·Shweta R Motiwala, Hanna K Gaggin
Jan 24, 2019·European Journal of Heart Failure·Gian Paolo Ussia
Jan 8, 2017·Clinical Chemistry·Nasrien E Ibrahim, James L Januzzi
Oct 26, 2018·Circulation Research·Nasrien E Ibrahim, James L Januzzi
Aug 15, 2017·Current Heart Failure Reports·Jeremy CypenAdam D DeVore
Mar 13, 2021·Journal of the American College of Cardiology·Inbar RaberJames L Januzzi

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