Concentrations of isoflavones in plasma and urine of post-menopausal women chronically ingesting high quantities of soy isoflavones

Journal of Pharmaceutical and Biomedical Analysis
J MatheyCatherine Bennetau-Pelissero

Abstract

Soy food or food supplements based on soy containing isoflavones (Isos) are increasingly available in Western countries. However, the variability of Isos levels in urine and plasma in humans during chronic ingestion is poorly documented. Nevertheless, this is the way these compounds will most probably be used in the future, especially if the soy-based supplements market goes on increasing. Here, glycosilated Isos in an enriched extract of Prevastein equal to 100 mg of equivalent Isos aglycone was given daily to 27 post-menopausal women for 30 days and to 12 post-menopausal women for 60 days. Volunteers were given Prevastein in a cereal bar (25 mg Isos) and in a yoghurt (25 mg Isos) both at breakfast and dinner. Plasma samples were collected after overnight fasting. Urine samples were aliquots of a 24 h collection checked on volume and creatinin excretion levels. Genistein, daidzein and equol were measured at day 0 and every 15 days afterwards, using original specific ELISAs. Constant levels were reached from the 15th day. About 59.2% of the volunteers were significant equol producers in the first experiment and 58.3% in the second. A large variability in plasma and urine levels was observed among post-menopausal women consuming...Continue Reading

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Citations

Mar 1, 2012·European Journal of Nutrition·Dana ShorNatalie J Thatcher
Jul 23, 2009·The British Journal of Nutrition·Sébastien VergneCatherine Bennetau-Pelissero
Jan 6, 2012·The British Journal of Nutrition·Rémy BosvielDominique Bernard-Gallon
May 15, 2007·Current Opinion in Obstetrics & Gynecology·Mhairi Cl West
Jun 5, 2008·Nutrition Journal·Mark J Messina, Charles E Wood
Jul 28, 2011·Nutrition Reviews·Richard L JacksonRichard J Schwen
Jan 8, 2009·Biochemical and Biophysical Research Communications·Maud PrivatYves-Jean Bignon
May 21, 2010·Molecular Nutrition & Food Research·Selin BolcaHerman Depypere
Mar 20, 2015·Neural Regeneration Research·Adem Bozkurt ArasMurat Cosar
Jan 9, 2015·Inflammation·Adem Bozkurt ArasMurat Cosar
Sep 8, 2012·Food Chemistry·Svitlana ShinkarukCatherine Bennetau-Pelissero
Mar 10, 2015·Clinical & Experimental Metastasis·Xujuan YangWilliam G Helferich
May 8, 2016·Toxicology and Applied Pharmacology·Guillermo Nicolás TocchettiAldo Domingo Mottino
Nov 3, 2011·PloS One·Timothy D HowardJanice D Wagner
Nov 18, 2006·Journal of Pharmaceutical and Biomedical Analysis·Sébastien VergnePatrick Sauvant
Jun 21, 2007·Molecular Nutrition & Food Research·Jian-Ping YuanXin Liu
Feb 19, 2010·The American Journal of Clinical Nutrition·Selin BolcaHerman Depypere
Oct 18, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Catherine Bennetau-Pelissero
Oct 2, 2019·Nutrients·Alexandre LeeCatherine Bennetau-Pelissero
Sep 15, 2018·Genes & Nutrition·Pedapati S C Sri HarshaLorraine Brennan
Jul 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yulin MaDerek A Schreihofer
Jan 1, 2008·Journal of Natural Products·Noël J-M RaynalRichard L Momparler
Jul 24, 2008·Journal of Agricultural and Food Chemistry·Svitlana ShinkarukCatherine Bennetau-Pelissero
May 15, 2007·Current Opinion in Obstetrics & Gynecology
Oct 2, 2021·Scientific Reports·Tomoko FujitaniKouji H Harada

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